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Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:
    • the modification of biochemical pathways inside cells and
    • the rigorous evaluation of the resulting cellular phenotypes.
Our most recent research has been focused on the following topics:
  • Metabolic Engineering of E.Coli for the production of biochemicals
  • Inverse Metabolic Engineering
  • gTME
  • Flux Determination
  • Hepatocyte Physiology
  • Metabolomics
  • Systems Biology

To accomplish the above goals we make use of a diverse array of scientific tools and methods, many of which have also become areas of research for our group:

  • <a href="Bioinfo.shtml">Bioinformatics and Systems Biology</a> - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
  • <a href="Fluxes.shtml">Methods for intracellular flux determination</a> - Fluxes are determined by material balancing, NMR fine spectra analysis and GC-MS measurements.
  • <a href="Microarray.shtml">DNA microarrays</a> - We have developed full genome microarrays for Synechocystis Sp., and partial microarrays for C. glutamicum, E. coli, and the mouse genomes.
  • <a href="BioReactor.shtml">Bioreaction network analysis.</a>

Massachusetts Institute of Technology
Department of Chemical Engineering
Cambridge, MA 02139
Room 56-469
Last Modified:
Monday, July 10th, 2006 - by afi.
office | 617.258.0398
lab | 617.253.6591
lab | 617.258.0349
lab | 617.253.6521
fax | 617.253.3122
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