Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:
the modification of biochemical pathways inside cells and
the rigorous evaluation of the resulting cellular phenotypes.
Our most recent research has been focused on the following topics:
Metabolic Engineering of E.Coli for the production of biochemicals
Inverse Metabolic Engineering
gTME
Flux Determination
Hepatocyte Physiology
Metabolomics
Systems Biology
To accomplish the above goals we make use of a diverse array of scientific tools and
methods, many of which have also become areas of research for our group:
Bioinformatics and Systems Biology - Our group was
one of the first to realize the importance of computational tools for handling the
large volume of data generated by microarrays and other technologies.
DNA microarrays - We have developed full
genome microarrays for Synechocystis Sp., and partial microarrays for
C. glutamicum, E. coli, and the mouse genomes.
