Streptomyces:Research: Difference between revisions
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Revision as of 04:34, 14 March 2007
Our research outline
ResearchGabriella KelemenKey Research InterestsOur main research interest is studying bacterial development of Streptomyces coelicolor, a Gram-positive, filamentous bacterium. Unlike most bacteria that divide by binary fission, in Streptomyces coelicolor long, multigenomic filaments are formed with ocasional septa and regular branching. Cell division is completed only during sporulation when 50-100 sporulation septa are laid down synchronously in the aerial hyphae generating unigenomic spore compartments. Current projects include:
Matt HutchingsKey Research InterestsIn order to survive, bacteria must sense and respond to their environment. One of the main ways in which bacteria do this is via two-component signal transduction pathways. In a typical two-component system the extracellular loop of the transmembrane sensor kinase senses a specific signal, autophosphorylates and passes that phosphate group to its cognate response regulator. The activated response regulator then switches on target genes to bring about a response to the original signal (Figure 1).
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