SynBERC:Parts
From OpenWetWare
This is a draft list of research topics that the SynBERC Parts Thrust is considering for support.
Please contribute & edit with impunity.
We need to get the set of topics correct and then organize ourselves (and anybody else who wants) around getting the work done.
I. Goals
1. Parts collection, registry
2. Parts characterization
3. Parts engineering
- a. New function
- b. Tune strength, timing
- c. Orthogonal, composable function
- d. Develop general methods for part redesign
II. Part Families
Transcriptional
- repressors, DNA binding proteins
- terminators
- promoters
Translational
- RBS
- Riboregulators
- mRNA procesing
Degradation
- degrons
Secretion
- Targeting sequences
Sensing/actuating
- protein binding
- small molecule ligand binding
- light sensing
- switches
Assembly
- Protein-protein interactions (orthogonal set)
Phosphorylation logic control
- Kinases
- Phosphatases
- Docking motifs
- phosphorecognition
Biosynthetic enzymes
Transporters
Cell adhesion
Chassis parts
- Vectors
- YAC components
- Transposon components