SynBERC:Parts

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This is a draft list of research topics that the SynBERC Parts Thrust is considering for support.
Please contribute & edit with impunity.
We need to get the set of topics correct and then organize ourselves (and anybody else who wants) around getting the work done.

Contents

I. Goals

1. Parts collection, registry

2. Parts characterization

3. Parts engineering

  • a. New function
  • b. Tune strength, timing
  • c. Orthogonal, composable function
  • d. Develop general methods for part redesign


II. Part Families

Transcriptional

  • repressors, DNA binding proteins
  • terminators
  • promoters

Translational

  • RBS
  • Riboregulators
  • mRNA procesing

Degradation

  • degrons

Secretion

  • Targeting sequences

Sensing/actuating

  • protein binding
  • small molecule ligand binding
  • light sensing
  • switches

Assembly

  • Protein-protein interactions (orthogonal set)

Phosphorylation logic control

  • Kinases
  • Phosphatases
  • Docking motifs
  • phosphorecognition

Biosynthetic enzymes

Transporters

Cell adhesion

Chassis parts

  • Vectors
  • YAC components
  • Transposon components
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