SynBERC:Seminar series/Remy Chait
Antibacterial drug combinations and evolution of drug resistance
Remy Chait, Harvard Systems Biology
April 24, 2007
The rapid evolution of bacterial drug resistance and the alarming slowdown in development of new antibiotics is spurring attention towards multi-drug treatments. But how do such treatments affect the rate of evolution of drug resistance? I will present a simple model and direct experimental measurements showing that non-additive interactions between the drugs can profoundly alter the fitness landscape, leading to surprising and counterintuitive outcomes.
- Chait R, Craney A, and Kishony R. . pmid:17410176.
A video stream of the talk will be available for real-time viewing. Just point Quicktime or VLC to the following stream:
Download the talk in quicktime format here, or go to blip.tv to see comments, get code to embed the video in your own webpage or blog (also visible by editing this page and looking below), and to watch or download the talk in alternate video formats (i.e. .flv). Or just watch it here: