User:Etienne Robillard/Notebook/THF

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== Name ==
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{{deleteme}}
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Tetrahydrofuran
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== Use ==
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Heterocyclic compound implicated in organic synthesis of unnatural amino acids, and most importantly as a miscible (anhydrous)
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reagent to synthetize N-substituted phenoxyalkylamines (ligands) using orthogonal (multi-step) catalysis of dicarboxilic protected C=N ions (imine)
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in [http://www2.chemistry.msu.edu/faculty/reusch/virttxtjml/aldket1.htm#rx1b nucleophilic carbonyl addition reactions].
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== N-substituted (cis/trans) phenoxyalkylation using Michael reaction of complex amino acids ==
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* a "alkane isomerisation" type of organic catalysis [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_14:_Reactions_with_stabilized_carbanion_intermediates_II/Section_14.2:_Variations_on_the_Michael_reaction 1]
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** [[User:Etienne Robillard|Etienne Robillard]] 10:35, 15 January 2013 (EST) Can aromatic nucleophilic substitution of a disubstituted phenoxyalkylamine produce para/ortho opioid ligand (L-dopamine for example) ? In this case, verify if the  N heterocycle ring is acting as the nucleophile (R) reagent in presence of an aldehyde...
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*** [[User:Etienne Robillard|Etienne Robillard]] 10:35, 15 January 2013 (EST) See also "Michael reaction" for a proper explanation.. :)
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* isopropanol can donate proton -- an aldehyde like solvent?
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** [[User:Etienne Robillard|Etienne Robillard]] 10:35, 15 January 2013 (EST) Can THF donate stuff with nucleophilic rings? ie cyclohexanoyl
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* alkane isomerisation = organic synthesis: L-dopamine, cyclohexylamine, etc..
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* Ethics of producing novel opioid receptor agonist compounds for human-specific psychotropic experiments?
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** [[User:Etienne Robillard|Etienne Robillard]] 10:35, 15 January 2013 (EST) Heck, is there a possibility theses novel psychotropic compounds be used by terrorist groups to terrorize unwary citizens with psychological warfare using unconventional (synthetic) "devices" ?
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== Related  chemicals ==
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* Benzylamine
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* Isopropanol
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* [[Piperidine]]
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== References ==
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1. Kim J., Recent Advances in Asymmetric Phase-Transfer-Catalysis, 2011 http://stoltz.caltech.edu/seminars/2011_Kim.pdf p. [1-25]
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== See also ==
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* Mannich/Michael reaction
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* Pictet-Spengler reaction
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* [[DMF]] - A THF analog (N,N-dimethylformamide)
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* [[Ethanamine]]
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* [http://en.wikipedia.org/wiki/Tetrahydrofolic_acid Tetrahydrofolic acid (THF) page on Wikipedia]
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[[Category:Chemical]]
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