TMT To Do List: Difference between revisions

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==Time Sensitive==
*Summarize committee meeting and prepare for meeting with Drew on Tuesday (email him to set up a time)


==Wiki==
*add multiplier for membrane interactions
*Fus3 phosph/dephosph
*Kss1 phosph/dephosph
*Kss1 phosph of Ste11, Sst2
*Scoring scheme for trust in given assumption
*means of attaching author to assumptions
*change naming from specific protein (Fus3, Ste7, etc) to protein family (MAPK, MAPKK, etc)
==Jacobian Bugs==
#Statistics from parameter estimation fails if there are more than 254 data points.
#*john can't duplicate
#When running estimation from script, you can't specify which parameter to estimate (parameter number can't be a variable), wheras when running estimation block directly, parameter number can be a variable.
#*not a bug
#Parameter sensitivities are not correct when the sequence section has a continue for 0 statement.
#*problem identified - will fix it
#Jacobian greatly slows down after ~80 simulations are run from a single script.
#*John can't duplicate
#Inconsistency with parameter variance in statistics of estimation report.
==Experimental==
*Get reporter working in glass bottom plate
*Get reporter working in [[Stimulator]]
*Check our microscope camera against molsci's (theirs is Micromax 512BFT)
==Paper with Kirsten==
*Look over ultrasensitivity papers
**what are mechnisms that cause ultrasensitivity, and why isn't pheromone response ultrasensitive
*Yildirim model
*Kofahl model
*What tidbits have I uncovered in model building
**Ste5 dimerization is sufficient to help explain published data (more detail).  Etc
*Email kirsten about Arkin paper. (model discrimination)
==Other==
*Email Roger re microfluidic flow cytometer.
*talk to kirsten about thesis committee meeting

Latest revision as of 16:39, 11 September 2007