Talk:CH391L/S12/CH391L/S12/Ancestral Sequence Reconstruction: Difference between revisions
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When you say that the ancestral species sequences are inferred from extant species, is that the sole source of sequence information, or has DNA also been extracted from fossils to gain information needed to synthesize biomolecules? [[User:Razan Alnahhas|Razan Alnahhas]] 00:56, 3 February 2012 (EST) | When you say that the ancestral species sequences are inferred from extant species, is that the sole source of sequence information, or has DNA also been extracted from fossils to gain information needed to synthesize biomolecules? [[User:Razan Alnahhas|Razan Alnahhas]] 00:56, 3 February 2012 (EST) | ||
*'''[[User:Jeffrey E. Barrick|Jeffrey E. Barrick]] 11:11, 5 February 2012 (EST)''':Cite the Pauling and Zuckerkandl paper as a reference? All of the phylogenetic methods have been around longer than sequence data, so I'm not sure "30 years before the phylogenetic methods" is quite correct. It's true that it was only possible to implement a lot of these with computers for larger data sets. | *'''[[User:Jeffrey E. Barrick|Jeffrey E. Barrick]] 11:11, 5 February 2012 (EST)''':Cite the Pauling and Zuckerkandl paper as a reference? All of the phylogenetic methods have been around longer than sequence data, so I'm not sure "30 years before the phylogenetic methods" is quite correct. It's true that it was only possible to implement a lot of these with computers for larger data sets. | ||
*'''[[User:Jeffrey E. Barrick|Jeffrey E. Barrick]] 11:17, 5 February 2012 (EST)''':Can you find a sequence alignment from a paper to use as an image that shows some extant sequences and the reconstructed ancestral sequence as an example? Either that or show a little picture of phylogenetic tree like you did in class and a simple scenario for inferring an ancestor? | *'''[[User:Jeffrey E. Barrick|Jeffrey E. Barrick]] 11:17, 5 February 2012 (EST)''':Can you find a sequence alignment from a paper to use as an image that shows some extant sequences and the reconstructed ancestral sequence as an example? Either that or show a little picture of phylogenetic tree like you did in class and a simple scenario for inferring an ancestor? | ||
Revision as of 08:43, 13 February 2012
When you say that the ancestral species sequences are inferred from extant species, is that the sole source of sequence information, or has DNA also been extracted from fossils to gain information needed to synthesize biomolecules? Razan Alnahhas 00:56, 3 February 2012 (EST)
- Jeffrey E. Barrick 11:11, 5 February 2012 (EST):Cite the Pauling and Zuckerkandl paper as a reference? All of the phylogenetic methods have been around longer than sequence data, so I'm not sure "30 years before the phylogenetic methods" is quite correct. It's true that it was only possible to implement a lot of these with computers for larger data sets.
- Jeffrey E. Barrick 11:17, 5 February 2012 (EST):Can you find a sequence alignment from a paper to use as an image that shows some extant sequences and the reconstructed ancestral sequence as an example? Either that or show a little picture of phylogenetic tree like you did in class and a simple scenario for inferring an ancestor?
