- Jeffrey E. Barrick 10:29, 6 April 2012 (EDT):Images need citations. Chili peppers are tiny?
- Jared Ellefson 18:17, 7 April 2012 (EDT):Fixed the chili problem. But it's not letting me add text to the figures? I'll keep working on it
- Jeffrey E. Barrick 10:29, 6 April 2012 (EDT):There's a nice presentation posted many places online, including here, which seems to contain unpublished computational modeling of more complex circuits and pattern formation, but without any wet lab work.
- Jared Ellefson 18:10, 7 April 2012 (EDT):I think this brings up an interesting topic. How much weight should a nontested biological model hold? I mean, it's obvious in every example that the idiosyncrasies of biology make it hard to guess whether or not this model would work at all. But that said, I'd be curious to see how that circuit would work, it has a very BZ reaction feel which is cool (http://www.youtube.com/watch?v=3JAqrRnKFHo).
- Jeffrey E. Barrick 10:29, 6 April 2012 (EDT):Your references aren't working correctly: the syntax for the end of the line is pmid=12219076
- Jared Ellefson 18:10, 7 April 2012 (EDT):Fixed
- Jeffrey E. Barrick 10:44, 6 April 2012 (EDT): Spelling: "achieved". First sentence of "Synthetic pattern formation..." needs help.
- Jared Ellefson 18:17, 7 April 2012 (EDT):ok
- Jeffrey E. Barrick 10:44, 6 April 2012 (EDT):Has anything "useful" ever been done with synthetic pattern formation? Do you think it would be possible to get noncircular colony growth for E. coli (or noncircular spreading in soft agar) by putting one of these circuits in that would "sector" the colony and change how it spread or something like that?
- Jared Ellefson 18:10, 7 April 2012 (EDT):Depends on the definition of useful. I certainly foresee this being an enabling technology. But I'm not sure how useful it will be in E.coli. The real biomedical applications might start to take place once systems like this are imported into mammalian cell culture. In terms of non-circular colony growth, yeah I bet this is possible. My guess is tricky though, if you're dealing with cell survival. I'm not sure the exact parameters you are thinking of (autonomous vs non-autonomous), but I bet you could do some fun stuff with light controlling cell growth.