Talk:CH391L/S12/ToxinAntitoxins

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*'''[[User:Jeffrey E. Barrick|Jeffrey E. Barrick]] 19:01, 26 February 2012 (EST)''':There are many toxin-antitoxin systems in the genomes of pathogens like ''Mycobacterium tuberculosis''. I've heard that they might contribute to the phenomenon of "persistence", but I don't know how the current evidence for this hypothesis weighs versus the evidence that TA modules are selfish elements that are actually slightly deleterious to carry around, but can accumulate in a genome over time during evolution at small population size when selection against slightly deleterious mutations is weak.
*'''[[User:Jeffrey E. Barrick|Jeffrey E. Barrick]] 19:01, 26 February 2012 (EST)''':There are many toxin-antitoxin systems in the genomes of pathogens like ''Mycobacterium tuberculosis''. I've heard that they might contribute to the phenomenon of "persistence", but I don't know how the current evidence for this hypothesis weighs versus the evidence that TA modules are selfish elements that are actually slightly deleterious to carry around, but can accumulate in a genome over time during evolution at small population size when selection against slightly deleterious mutations is weak.
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:*'''[[User:Brian Renda|Brian Renda]] 22:06, 26 February 2012 (EST)''':A somewhat recent publication look at the relationship of persistence and TA loci in ''E. coli'' <cite>Maisonneuve2011</cite>. They found that deleting individual loci had no effect on persistence. However, when they deleted more and more loci, they noticed a correlative drop in persistence. The first significant difference was at about 4-5 loci and at 10 loci deletions, persistence in antibiotics dropped 100-200 fold. They mention in the discussion that this phenomena helps explain the extreme persistence of ''Mycobacterium tuberculosis'', which contains at least 88 TA loci with a heavy preference towards translation inhibitors.
*'''[[User:Adam Meyer|Adam Meyer]] 21:55, 26 February 2012 (EST)''':Are there any instances of labs/companies using a TA system (A) in the place of antibiotics or (B) as a failsafe or intellectual property protection method?
*'''[[User:Adam Meyer|Adam Meyer]] 21:55, 26 February 2012 (EST)''':Are there any instances of labs/companies using a TA system (A) in the place of antibiotics or (B) as a failsafe or intellectual property protection method?
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<biblio>
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#Maisonneuve2011 pmid= 21788497
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</biblio>

Revision as of 23:06, 26 February 2012


  • Jeffrey E. Barrick 00:14, 25 February 2012 (EST):Please, italicize species names like E. coli.
  • Jeffrey E. Barrick 19:01, 26 February 2012 (EST):There are many toxin-antitoxin systems in the genomes of pathogens like Mycobacterium tuberculosis. I've heard that they might contribute to the phenomenon of "persistence", but I don't know how the current evidence for this hypothesis weighs versus the evidence that TA modules are selfish elements that are actually slightly deleterious to carry around, but can accumulate in a genome over time during evolution at small population size when selection against slightly deleterious mutations is weak.
  • Brian Renda 22:06, 26 February 2012 (EST):A somewhat recent publication look at the relationship of persistence and TA loci in E. coli [1]. They found that deleting individual loci had no effect on persistence. However, when they deleted more and more loci, they noticed a correlative drop in persistence. The first significant difference was at about 4-5 loci and at 10 loci deletions, persistence in antibiotics dropped 100-200 fold. They mention in the discussion that this phenomena helps explain the extreme persistence of Mycobacterium tuberculosis, which contains at least 88 TA loci with a heavy preference towards translation inhibitors.
  • Adam Meyer 21:55, 26 February 2012 (EST):Are there any instances of labs/companies using a TA system (A) in the place of antibiotics or (B) as a failsafe or intellectual property protection method?


  1. pmid= 21788497 [Maisonneuve2011]
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