Talk:Todd:Catalytic, Asymmetric Pictet-Spengler Reaction: Difference between revisions

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(comment about length of review and whether we need sections on different pages)
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They also mentioned "hydrolysis of the starting material" numerous times.  I'm assuming they mean hydrolysis of the N-S bond (there doesn't seem any other reasonable place for hydrolysis of the SM to occur), but I just wanted to check.
They also mentioned "hydrolysis of the starting material" numerous times.  I'm assuming they mean hydrolysis of the N-S bond (there doesn't seem any other reasonable place for hydrolysis of the SM to occur), but I just wanted to check.
Interesting that the chirality of CSA doesn't affect the ee. Unlike the conjugate BINOL base acting as the counterion in Dixon 2010.

Revision as of 17:22, 19 January 2012

Use this page for discussion. Preface questions/comments with initials.

MHT - Jan19 - the page is quite long. We could consider splitting into sections if anyone is having a browser problem, but otherwise we keep as-is. Much more convenient having everything on one page.


Archived/inactive discussions:

1. KAB attempt to understand 2000 Koomen OrgLett (archived since this paper no longer included)

The figure for Table 1 gives diasteromeric ratios. Where are the diastereomers? I only the possibility for enantiomers in the product. Where's the other stereogenic centre?

They also mentioned "hydrolysis of the starting material" numerous times. I'm assuming they mean hydrolysis of the N-S bond (there doesn't seem any other reasonable place for hydrolysis of the SM to occur), but I just wanted to check.