Tamoxifen administration to mice
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| - | * | + | * [http://en.wikipedia.org/wiki/Tamoxifen Tamoxifen in Wikipedia] |
Revision as of 07:12, 26 April 2007
One of the uses of tamoxifen in the lab is the activation of enzymes deactivated via an estrogen-binding domain, like Cre-ER (Cre-LBD). Tamoxifen is an estrogen analogue that binds with higher affinity than estrogen to altered estrogen binding domains.
Tamoxifen is administered to mice in 2 main ways: via the drinking water or in an oily mix given via a feeding needle. Administration via the drinking water is easier but somewhat less reliable.
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