Tamoxifen administration to mice: Difference between revisions
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Tamoxifen is administered to mice in 2 main ways: via the drinking water or in an oily mix given via a feeding needle. Administration via the drinking water is easier but somewhat less reliable. | Tamoxifen is administered to mice in 2 main ways: via the drinking water or in an oily mix given via a feeding needle. Administration via the drinking water is easier but somewhat less reliable. | ||
== Chemical data for tamoxifen == | == Chemical data for tamoxifen citrate== | ||
{| border=1 cellpadding=5 cellspacing=0 | |||
|- | |||
| molecular weight | |||
| pKa' | |||
| equilibrium solubility in water at 37°C | |||
|- | |||
| 563.62 g/mol | |||
| 8.85 | |||
| 0.5 mg/mL | |||
|} | |||
see [http://www.rxlist.com/cgi/generic/tamox.htm] | |||
== Tamoxifen administration via the drinking water == | == Tamoxifen administration via the drinking water == | ||
Revision as of 04:16, 26 April 2007
One of the uses of tamoxifen in the lab is the activation of enzymes deactivated via an estrogen-binding domain, like Cre-ER (Cre-LBD). Tamoxifen is an estrogen analogue that binds with higher affinity than estrogen to altered estrogen binding domains.
Tamoxifen is administered to mice in 2 main ways: via the drinking water or in an oily mix given via a feeding needle. Administration via the drinking water is easier but somewhat less reliable.
Chemical data for tamoxifen citrate
| molecular weight | pKa' | equilibrium solubility in water at 37°C |
| 563.62 g/mol | 8.85 | 0.5 mg/mL |
see [1]
