Tamoxifen administration to mice
From OpenWetWare
One of the uses of tamoxifen in the lab is the activation of enzymes deactivated via an estrogen-binding domain, like Cre-ER (Cre-LBD). Tamoxifen is an estrogen analogue that binds with higher affinity than estrogen to altered estrogen binding domains.
Tamoxifen is administered to mice in 2 main ways: via the drinking water or in an oily mix given via a feeding needle. Administration via the drinking water is easier but somewhat less reliable.
Chemical data for tamoxifen citrate
molecular weight | pKa' | equilibrium solubility in water at 37°C |
563.62 g/mol | 8.85 | 0.5 mg/mL |
see [1]