Template:NcbiGeneACCN1

NCBI GeneID

40

Official Symbol

ACCN1

Full Name

amiloride-sensitive cation channel 1, neuronal

Location

17q12

See related

HGNC:99 Ensembl:ENSG00000108684 HPRD:03471 MIM:601784

Other Names

ACCN; BNC1; MDEG; ASIC2; BNaC1; ASIC2a; hBNaC1;

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

ACCN1

"This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified"