Theilmeier Lab

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Research Group Leader

Gregor Theilmeier, MD

<showhide>== Contact Information == __HIDER__ <hide> Institute for Anatomy
and Department of Anesthesiology and Intensive Care Medicine
University Hospital Muenster, Germany
Vesaliusweg 2-4
48149 Muenster
Germany

phone: +49 251 8356498
fax: +49 251 8355241
email: theilmeier@anit.uni-muenster.de

</hide></showhide>

<showhide>== Lab Members == AGhurra.jpg
__HIDER__ <hide> Researchers

Technical staff

  • Annelie Ahle
  • Daniela Aschoff
  • Stephan Brodner
  • Gisela Gaede
  • Manfred Greiwe
  • Stefan Lütke Enking
  • Ulrike Niehues
  • Dirk Reinhard
  • Cordula Westermann

Graduate Students

Alumni

  • Jan Mersmann, MD

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Research interest

<showhide> The research activities of our group relate largely to the identification of modulators of inflammation in tissues following transient ischemia or hypoxia.
__HIDER__ <hide>

We have been working on the role of the urokinase receptor as well as the lectin-like domain of thrombomodulin with respect to their potential to reduce reperfusion injury while allowing for better regeneration of the damaged tissue. Our focus has been the heart but we are moving on to global ischemia with the ensuing systemic inflammatory response syndrome related to cardiac arrest. The group consists of 7 postdoctoral fellows, 8 technicians and several medical students. In the center of our activities we utilize clinically relevant mouse models of human diseases like myocardial infarction, cardiac arrest and resuscitation, cardiac hypertrophy and atherosclerosis. The animals are examined with respect to their functional recovery using echocardiography, PET, ECG, blood pressure measurements and parameters for organ function. We then characterize the cellular response to the lack of certain gene products immunohistochemically, biochemically and with a broad range of molecular biology techniques. We express molecules of interest as recombinant proteins and gene therapeutic approaches in the in vivo models and in in vitro assays of leukocyte adhesion with respect to their mechanism of action and their therapeutic potential. </hide></showhide> <showhide>== Selected Publications == __HIDER__ <hide>

1. Tsao P, Theilmeier G, Singer A, Leung K, Cooke J: Increased platelet aggregation in hypercholesterolemic rabbits is reduced by dietary L-arginine. ArteriosclerThrombVascBiol 1994; 14 (10): 1529-33.
2. Theilmeier G, Chan J., Zalpour C., Anderson B, Wang BY, Wolf A, Tsao P, Cooke J.: Adhesiveness of mononuclear cells in hypercholesterolemic humans is normalized by dietary arginine; ArteriosclerThrombVascBiol 1997; 17: 3557 - 64.
3. Holvoet P., Theilmeier G., Shivalkar B. Flameng W., Collen D.: LDL hypercholesterolemia is associated with accumulation of oxidized LDL, atherosclerotic plaque growth and compensatory vessel enlargement in coronary arteries of miniature pigs. ArteriosclerThrombVascBiol 1998; 18:415-422.
4. Carmeliet P, Ng YS, Nuyens D, Theilmeier G, Brusselmans K, Cornelissen I, Ehler E, Kakkar VV, Stalmans I, Mattot V, Perriard JC, Dewerchin M, Flameng W, Nagy A, Lupu F, Moons L, Collen D, D'Amore PA, Shimam DT.: Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nature Medicine 1999; 5 (5): 495 502
5. Heymans S, Luttun A, Nuyens D, Theilmeier G, Creemers E, Moons L, Dyspersin GD, Cleutjens JP, Shipley M, Angellilo A, Levi M, Nube O, Baker A, Keshet E, Lupu F, Herbert JM, Smits JF, Shapiro SD, Baes M, Borgers M, Collen D, Daemen MJ, Carmeliet P.: Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nature Medicine 1999; 5 (10): 1135 42
6. Theilmeier G, Lenaerts T, Remacle C, Collen D, Vermylen J, Hoylaerts MF.: Circulating activated platelets assist THP-1 monocytoid/endothelial cell interaction under shear stress. Blood 1999; 94 (8): 2725-34
7. Theilmeier G, De Geest B, Van Veldhoven PP, Stengel D, Michiels C, Lox M, Landeloos M, Chapman MJ, Ninio E, Collen D, Himpens B, Holvoet P. HDL-associated PAF-AH reduces endothelial adhesiveness in apoE-/- mice. FASEB J. Oct;14(13):2032-9 (2000).
8. Theilmeier G, Michiels C, Spaepen E, Vreys I, Collen D, Vermylen J, Hoylaerts MF. Endothelial von Willebrand factor recruits platelets to atherosclerosis-prone sites in response to hypercholesterolemia. Blood. 15;99(12):4486-93 (2002).
9. Theilmeier G, Quarck R, Verhamme P, Bochaton-Piallat ML, Lox M, Bernar H, Janssens S, Kockx M, Gabbiani G, Collen D, Holvoet P. Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplasty. Cardiovasc Res. 55(2):385-95 (2002).
10. Theilmeier G, Verhamme P, Dymarkowski S, Beck H, Bernar H, Lox M, Janssens S, Herregods M-C, Verbeken E, Collen D, Plate K, Flameng W, Holvoet P, Hypercholesterolemia in Minipigs Impairs Left Ventricular Response to Stress – Association with Decreased Coronary Flow Reserve and Reduced Capillary Density. Circulation. 2002;106(9):1140-6.
11. Conway EM, Van de Wouwer M., Pollefeyt S, Jurk K, Van Aken HK, deVriese A, Weitz JI, Weiler H, Hellings P, Schaeffer P, Herbert JM, Collen D, Theilmeier G. The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via NFκB and MAP kinase pathways. J Exp Med 2002; 196(5): 565-577.
12. Pislaru SV, Van Ranst M, Pislaru C, Szelid Z, Theilmeier G, Ossewaarde JM, Holvoet P, Janssens S, Verbeken E, Van de Werf FJ. Chlamydia pneumoniae induces neointima formation in coronary arteries of normal pigs. Cardiovasc Res. 2003; 57(3): 834-42.
13. Larmann J, Theilmeier G.: Inflammatory response to cardiac surgery: cardiopulmonary bypass versus non-cardiopulmonary bypass surgery. Best Pract Res Clin Anaesthesiol. 2004;18(3):425-38.
14. Levkau B, Hermann S., Theilmeier G, van der Giet M, Chun J, Schober O, Schäfers M. HDL stimulates myocardial perfusion in vivo. Circulation, 2004; 110: 3355-9.
15. Larmann J, Schmidt C, Gammelin H, Van Aken HK, Frenzel T, Lanckohr C, Lox M, Boese N, Jurk K, Theilmeier G. ICAM-1-Inhibition ameliorates neurological and hepatic damage after resuscitation in mice. Anesthesiology 2005, 103: 1-6
16. Schmidt C, Theilmeier G, Van Aken H, Korsmeier P, Wirtz SP, Berendes E, Hoffmeier A, Meissner A. Comparison of electrical velocimetry and transoesophageal Doppler echocardiography for measuring stroke volume and cardiac output. Br J Anaesth. 2005; 95(5):603-10
18. Hahnenkamp K, Durieux ME, Hahnenkamp A, Schauerte SK, Hoenemann CW, Vegh V, Theilmeier G, Hollmann MW. Local anaesthetics inhibit signalling of human NMDA receptors recombinantly expressed in Xenopus laevis oocytes: role of protein kinase C. Br J Anaesth. 2006; 96(1):77-87
19. Bremer C, Ntziachristos V, Weitkamp B, Theilmeier G, Heindel W, Weissleder R. Optical imaging of spontaneous breast tumors using protease sensing 'smart' optical probes. Invest Radiol. 2005; 40(6):321-7.
20. Schmidt C, Theilmeier G, Van Aken H, Korsmeier P, Wirtz SP, Berendes E, Hoffmeier A, Meissner A. Comparison of electrical velocimetry and transoesophageal Doppler echocardiography for measuring stroke volume and cardiac output. Br J Anaesth. 2005; 95(5):603-10
21. Frenzel T., Theilmeier G. Pathophysiology of coronary artery disease and heart failure AINS 2006; 41(5):315-2
22. Theilmeier G, Schmidt C, Herrmann J, Keul P, Schäfers M, Herrgott I, Mersmann J, Larmann J, Hermann S, Stypmann J, Schober O, Hildebrand R, Schulz R, Heusch G, Haude M, Wnuck Lipinski von K, Herzog C, Schmitz M, Erbel R, Chun J, Levkau B. High-Density Lipoproteins and Their Constituent, Sphingosine-1-Phosphate, Directly Protect the Heart Against Ischemia/Reperfusion Injury In Vivo via the S1P3 Lysophospholipid Receptor. Circulation. 2006;114:1403-1409. </hide></showhide>


<showhide>== Collaborations == __HIDER__ <hide> University of Münster, Germany

University of Essen, Germany

KU Leuven, Belgium

  • Peter Carmeliet - Center for Transgene Technology and Gene Therapy
  • Ed Conway - Center for Transgene Technology and Gene Therapy

University of Bristol, UK

UCSF

Stanford

  • Phil Tsao - Division of Cardiovascular Medicine

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