Tim Frenzel

personal

Welcome to my homepage at OpenWetWare!

I'm an Anesthesiologist and Intensivist (since 08/2011) at the Department of Intensive Care Medicine (H van der Hoeven, MD, PhD), University Hospital Nijmegen, in The Netherlands.

Before I did a fellowship in Intensive Care Medicine (until 07/2011) at the same department.

I have earned the European diplomas in Anesthesiology (D.E.S.A., 2010) and in Intensive Care (EDIC, 2012).

Until July 2010 I used to work as an Anesthesiologist at the Department of Anesthesiology and Intensive Care (H van Aken, MD), University Hospital Muenster, Germany,
and was a member of the Collaborative Research Center (SFB) 656 MoBil: "Molecular Cardiovascular Imaging - from mouse to man", Muenster, Germany and
a Research Fellow at the Theilmeier Lab.

Since 2008 I have been working as Emergency physician (Notarzt) and physician for interhospital transport of critically ill patients at Berufsfeuerwehr Muenster, Berufsfeuerwehr Dortmund, Kreis Steinfurt and Kreis Kleve, Germany.

From 02/2006 until 03/2007 I was doing a Postdoc at Dr. Young/Dr. Yang's lab at the Center for Cerebrovascular Research
at the Department of Anesthesia (R Miller, MD) at University of California, San Francisco (UCSF), CA, USA.

In my "earlier" life I was working as a volunteer at an ambulance service, gave first-aid-classes and worked in the management of a local civil protection service.


Here you find my researchgate site.


OWW users: send me an email.
@mail: t (DOT) frenzel (AT) ic (DOT) umcn (DOT) nl
office: +31 24 3611111

current address:
Dept. of Intensive Care Medicine
Universityhospital Nijmegen
Huispost Nr. 707 Postbus 9101
6500HB Nijmegen
The Netherlands

research interests

• modulation of inflammation (e.g. reperfusion injury after myocardial ischemia, cerebral ischemia or circulatory arrest)
  
• molecular and cellular optical imaging in vivo
  
• clinical research in critical care and transfusion medicine
  

bio

current position

• Intensivist and Anesthesiologist at the Department of Intensive Care Medicine (H van der Hoeven, MD, PhD), University Hospital Nijmegen, The Netherlands (since 08/2011).

professional training

• Fellowship in Intensive Care Medicine at the Department of Intensive Care Medicine (H van der Hoeven, MD, PhD), University Hospital Nijmegen, Netherlands (until 07/2011).
• Anesthesiologist at Department of Anesthesiology and Intensive Care (H van Aken, MD), Germany (until 07/2010).
• Emergency physician (Notarzt) and physician for interhospital transport of critically ill patients at Berufsfeuerwehr Muenster, Berufsfeuerwehr Dortmund, Kreis Steinfurt and Kreis Kleve, Germany (since 03/2008).
• Visiting Postdoc at Dr. Young/Dr. Yang's lab at the Center for Cerebrovascular Research

at the Department of Anesthesia (R Miller, MD) at University of California, San Francisco (UCSF), CA, USA (02/2006 to 03/2007)

• Member of the Collaborative Research Center (SFB) 656 MoBil: "Molecular Cardiovascular Imaging - from mouse to man", Muenster, Germany (since 07/2005)
• Research fellow at Theilmeier Lab (2005 to 2009)
• Residency at Department of Anesthesiology and Intensive Care (H van Aken, MD) (08/2004 to 02/2010)
  
• Paramedic at Malteser Ambulance Service Konstanz, Germany (1993-1997)
  

professional certifications

• EDIC, European Diploma in Intensive Care (European Society for Intensive Care Medicine, Europe) (12/2012)
  
• In training for Antibiotic Stewardship (German Association for Infectiology)
• Final exam transesophageal echocardiography (German Association for Anesthesiology & Intensive Care Medicine, DGAI, Germany) (07/2010)
• D.E.S.A., European Diploma in Anesthesiology & Intensive Care (European Society for Anesthesiology, Europe) (03/2010)
  
• Diploma in mountain medicine (3 courses in medicine of high altitudes and mountain medicine) Austrian Association for alpine and high altitude medicine, recognized by UIAA, IKAR, ISMM (2008-2010)
  
• Course in prehospital trauma management ("Trauma Konzept" Berufsfeuerwehr Muenster, Germany) (03/2010)
  
• Anesthesiologist (Facharzt fuer Anaesthesiologie, Germany) (02/2010)
  
• Doctoral thesis (summa cum laude, Promotion zum Dr. med., Fakultaet fuer Medizin, Universitaet Muenster, Germany) (2009)
  
• Doctor for interhospital transport of critically ill patients (German Association for interdisciplinary Intensive Care Medicine, DIVI, Germany) (08/2008)
  
• Emergency doctor (Fachkunde Rettungsdienst/Zusatzbezeichnung Notfallmedizin) (Germany) (03/2008)
  
• Paramedic (Rettungssanitaeter, Germany) (1993)

education

• Doctoral thesis (summa cum laude, Promotion zum Dr. med., Fakultaet fuer Medizin, Universitaet Muenster, Germany) (2009)
• Medical School at Friedrich-Schiller-University, Jena, Germany
  
• Medical School at University of Cape Town, South Africa (2003)
  
• Medical School at Universitat Autonoma, Barcelona, Spain (2001)
  
• School for Economics at Friedrich-Schiller-University, Jena, Germany
  

awards

• Kosaka Award, 1st place, IARS (2007)
  
• Kosaka Award, 2nd place, IARS (2006)
  
• AAAS/Science Program for Excellence in Science (2006)
  
• Heinrich-Hertz foundation scholarship, federal state of NRW, Germany (2006)
  
• ERASMUS scholarship (2001)
  
• Special Award, German Nationwide Environmental Competition (1994)
  

professional memberships

• German Association for High Altitude and Expedition Medicine (BexMed)
  
• Dutch Association for Intensive Care Medicine (NVIC)
  
• International Anesthesia Research Society (IARS)
  
• German Society for Anesthesiology and Intensive Care Medicine (DGAI)
  
• Subcommitee "Junior Investigators" (DGAI)
  
• American Heart Association
  
• American Association for the Advancement of Science via AAAS/Science Program for Excellence in Science
  

extracurricular activities

• Chief Resident, Dept. of Anesthesiology and perioperative Intensive Care, University Hospital Muenster, Germany (2008-2010)
• Member of faculty-parliament, Medical School, Muenster, Germany (2008-2010)
• Member of faculty-parliament, Medical School, Jena, Germany (1999-2004)
• Member of senate, Friedrich Schiller-University, Jena, Germany (2002-2003)
• Founding member of EMSA Jena (European Medical Students’ Organization)

Advisory Function on local and european level

publications

(pubmed)

• Larmann J*, Frenzel T*, Schmitz M, Hahnenkamp A, Demmer P, Immenschuh S, Tietge UJ, Bremer C, Theilmeier G. In Vivo Fluorescence-mediated Tomography Imaging Demonstrates Atorvastatin-mediated Reduction of Lesion Macrophages in ApoE-/- Mice. Anesthesiology. 2013 Apr 2. [Epub ahead of print]
  

• Larmann J, Frenzel T, Hahnenkamp A, Herzog C, Lorenz A, Steinbicker AU, Calmer S, Harendza T, Schmitz M, Echtermeyer F, Hildebrand R, Bremer C, Theilmeier G. In vivo fluorescence-mediated tomography for quantification of urokinase receptor-dependent leukocyte trafficking in inflammation. Anesthesiology. 2010 Sep;113(3):610-8
  

• Fan Y, Shen F, Frenzel T, Zhu W, Ye J, Liu J, Chen Y, Su H, Young WL, Yang GY. Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Ann Neurol. 2010 Apr;67(4):488-97
  

• Zhu W, Fan Y, Frenzel T, Gasmi M, Bartus RT, Young WL, Yang GY, Chen Y. Insulin Growth Factor-1 Gene Transfer Enhances Neurovascular Remodeling and Improves Long-Term Stroke Outcome in Mice. Stroke. 2008 Feb 28 [Epub ahead of print]
  

• Frenzel T, Lee C, Kim H, Quinnine N, Hashimoto T, Lawton M, Guglielmo J, McCulloch C, Young W. Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance. Cerebrovasc Dis. 2008;25(1-2):157-63
  

• Larmann J, Schmidt C, Gammelin H, Van Aken HK, Frenzel T, Lanckohr C, Lox M, Boese N, Jurk K, Theilmeier G. ICAM-1-Inhibition ameliorates neurological and hepatic damage after resuscitation in mice. Anesthesiology 2005, 103: 1-6
  

reviews

• Frenzel T, Westphal-Varghese B, Westphal M. Role of storage of red blood cells on microcirclation and tissue oxygenation in critically ill patients. Curr Opin Anaesthesiol. 2009 Apr;22(2):275-80
  

• Frenzel T, Westphal M. Role of the microcirculation in intensive care and resuscitation: the devil is in the details. Curr Opin Anaesthesiol. 2009 Apr;22(2):141-2
  

• Frenzel T, Van Aken H, Westphal M. Our own blood is still the best thing to have in our veins. Curr Opin Anaesthesiol. 2008 Oct;21(5):657-63
  

• Frenzel T, Theilmeier G. Pathophysiology of coronary artery disease and heart failure. Anasthesiol Intensivmed Notfallmed Schmerzther. 2006 May;41(5):315-21
  

case reports and other publications

• Mourad SM, Mies R, Frenzel T, Willems S, van der Heijden E, Schultze Kool LJ. A pregnant patient with spontaneous haemothorax: hereditary haemorrhagic telangiectasia in pregnancy. Ned Tijdschr Geneeskd. 2016;160(0):A9948.
  
• Frenzel T, Sibrowski W, Westphal M. Red-cell storage and complications of cardiac surgery. N Engl J Med. 2008 Jun 26;358(26):2841; author reply 2841-2.
  

abstracts (selection)

• Hucklenbruch C, Lunardi N, Frenzel T, Van Aken H, Jevtovic-Todorovic V. Isofluran beeinträchtigt die Proliferation unreifer Gliazellen von Ratten in vitro. DAC, Leipzig, Germany 2009
  

• Frenzel T, Fanxia S, Herzog C, Gabriel R, Larmann J, Lanckohr C, Carmeliet P, Young WL, Theilmeier G, Yang G. Urokinase-type Plasminogen Aktivator Rezeptor (u-PAR) Defizienz reduziert die Infarktgrösse und verbessert das neurologische Outcome nach fokaler zerebraler Ischämie und Reperfusion in der Maus. DAC, Hamburg, Germany 2007
  

• Frenzel T, Larmann J, Schmitz M, Lanckohr C, Theilmeier G, Bremer C. Nicht-Invasives In Vivo Tracking nah-infrarot Fluoreszenz-markierter Makrophagen in Atherosklerotische Läsionen mittels Fluoreszenz-mediierter-Tomographie (FMT). DAC, Hamburg, Germany 2007
  

• Larmann J, Frenzel T, Hahnenkamp A, Swintek A, Bremer C, Theilmeier G. In Vivo Tracking of Macrophage Recruitment into the Inflamed Peritoneum in Mice by Fluorescence Mediated Tomography. IARS 81st Clinical & Scientific Congress, Orlando, FL, USA 2007
  

• Frenzel T, Fanxia S, Larmann J, Young WL, Theilmeier G, Yang G. Urokinase-type Plasminogen Activator Receptor (u-PAR) Deficiency Reduces Infarct Size and Improves Neurological Outcome after Cerbral Ischemia and Reperfusion in Mice. IARS 81st Clinical & Scientific Congress, Orlando, FL, USA 2007
  

• Lanckohr C, Hahnenkamp A, Frenzel T, Mooren FC, Stypmann J, Theilmeier G. Exercise Induced Ventricular Hypertrophy Enlarges Myocardial Damage After Ischemia in Mice. IARS 81st Clinical & Scientific Congress, Orlando, FL, USA 2007
  

• Frenzel T, Larmann J, Schmitz M, Wallbrunn A, Lanckohr C, Theilmeier G, Bremer C. Non-invasive In Vivo Optical Tracking of Macrophage Recruitment to Atherosclerotic Injuries Using Fluorescence Mediated Tomography in Mice . International Stroke Conference, San Francisco, CA, USA 2007
  

• Frenzel T, Schmitz M, Wallbrunn A, Lanckohr C, Bremer C, Theilmeier G. In Vivo Optical Tracking of Macrophage Rrecruitment to Ischemic Myocardium using Fluorescence Mediated Tomography (FMT) in Mice. IARS 80th Clinical & Scientific Congress, San Francisco, CA, USA 2006
  

• Frenzel T, Odyvanova L, Kroll T, Sänger J, Höffken K, Clement JH, Wölfl S. Expression of BMPs and BMP associated genes in lung cancer. Deutscher Krebskongress, 2002

links

• protocol collection

• upcoming deadlines

• misc

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