Turnbaugh:Research

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Inactivation of cardiac drugs by gut microbes

We are using cell culture, mass spectrometry, and studies in gnotobiotic mice (germ-free and colonized) to determine the mechanism of reduction of digoxin and other cardiac glycosides by members of the gut microbiota, and to determine whether or not it is possible to limit this reaction in vivo.

Single cell methods for analyzing microbial physiology and gene content

We are using flow cytometry and microfluidics to analyze complex microbial communities collected from the human gut at single cell resolution. These techniques allow us to determine the baseline physiology, activity, and gene content of gut microbes, and how these factors are shaped by clinically relevant perturbations, i.e. exposure to host-targeted drugs and antibiotics.

The role of diet and surgery in shaping the gut microbiome and host metabolic outcomes

We are studying how Roux-en-Y gastric bypass surgery re-shapes the gut microbiota, and to what degree these changes contribute to the metabolic outcomes of surgery (in collaboration with Lee Kaplan group at Mass General Hospital). We are also performing experiments on the role of diet in shaping gut microbial ecology.

Data

Data can be analyzed in MGRAST
Raw datasets are available from GEO and NCBI-SRA
See Gordon lab website for previous manuscript supporting information Supplementary Data

Selected Press Articles

ScienceNOW article on calorie labels Harvard Gazette piece on our latest paper in Cell Nature 2012 Editor's Choice, Biotechniques piece on microfluidics, Harvard Gazette write-up on the Turnbaugh lab, Human Microbiome Project, Systems Biology Paper out in PNAS, Science Podcast on detecting novel associations, Wired Microbiome Atlas, Nature News, National Public Radio spot 2009, Economist, Nature video about obesity, New York Times Fat Factors, Nature News 2006, National Public Radio spot 2006, Nature Podcast transcript 2006

Outreach

Exploring Biodiversity Lecture


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