Turnbaugh:Research: Difference between revisions
No edit summary |
No edit summary |
||
| (25 intermediate revisions by the same user not shown) | |||
| Line 15: | Line 15: | ||
==Data== | ==Data== | ||
Data can be analyzed in [http://metagenomics.anl.gov MGRAST]<br> | Data can be analyzed in [http://metagenomics.anl.gov/?page=MetagenomeSearch&init_search=turnbaugh MGRAST]<br> | ||
Raw datasets are available from [http://www.ncbi.nlm.nih.gov/ | Raw datasets are available from [http://www.ncbi.nlm.nih.gov/gds/?term=turnbaugh GEO] and [http://www.ncbi.nlm.nih.gov/sra/?term=turnbaugh NCBI-SRA]<br> | ||
See Gordon lab website for previous manuscript supporting information [http://gordonlab.wustl.edu/SuppData.html Supplementary Data] | See Gordon lab website for previous manuscript supporting information [http://gordonlab.wustl.edu/SuppData.html Supplementary Data] | ||
==Selected Press Articles== | ==Selected Press Articles== | ||
Diet rapidly changes our gut microbes: | |||
[http://news.harvard.edu/gazette/story/2014/01/your-guts-what-you-eat-too/?utm_source=SilverpopMailing&utm_medium=email&utm_campaign=01.06%201 Harvard Gazette] | |||
[http://www.bloomberg.com/news/2013-12-11/diet-changes-gut-bacteria-within-a-day-harvard-study-finds.html Bloomberg] | |||
[http://www.newscientist.com/article/mg22029473.400-diet-switch-sparks-gut-bug-revolution-in-just-24-hours.html#.Uqi7IWRDt8s New Scientist] | |||
[http://news.sciencemag.org/biology/2013/12/extreme-diets-can-quickly-alter-gut-bacteria Science] | |||
[http://www.npr.org/blogs/thesalt/2013/12/10/250007042/chowing-down-on-meat-and-dairy-alters-gut-bacteria-a-lot-and-quickly NPR] | |||
[http://commonhealth.wbur.org/2013/12/day-microbiome-high-fat-nature KWUR] | |||
[http://phenomena.nationalgeographic.com/2013/12/11/you-are-what-you-eat-all-100-trillion-of-you/ National Geographic] | |||
[http://www.chicagotribune.com/news/sns-wp-blm-news-bc-diet11-20131211,0,5343952.story Chicago Tribune] | |||
[http://health.usnews.com/health-news/news/articles/2013/12/11/gut-bacteria-shift-quickly-after-changes-in-diet-study-shows US News] | |||
[http://www.the-scientist.com/?articles.view/articleNo/38643/title/Gut-Bacteria-Vary-with-Diet/ Scientist] | |||
[http://obs.rc.fas.harvard.edu/turnbaugh/Metagenomicist.mp3 You're the Expert podcast] | |||
Our recent paper on digoxin: | |||
[http://news.harvard.edu/gazette/story/2013/07/bacterial-blockade/ Harvard Gazette] | |||
[http://www.sciencenews.org/view/generic/id/351752/description/Gut_microbes_get__first_dibs_on_heart_meds Science News] | |||
[http://www.thenakedscientists.com/HTML/news/news/1000259/ Naked Scientists] | |||
[http://www.medicaldaily.com/articles/17543/20130718/gut-bacteria-heart-prescription-drugs-drug-effectiveness-digoxin.htm Medical Daily] | |||
Links between obesity and cancer: | |||
[http://www.scientificamerican.com/article.cfm?id=gut-microbes-spur-liver-cancer-in-obese-mice Scientific American] | |||
[http://news.sciencemag.org/sciencenow/2013/06/gut-bugs-could-explain-obesity-c.html?ref=hp Science] | |||
[http://www.the-scientist.com/?articles.view/articleNo/36204/title/Obesity-Cancer-Link-Detailed/ The Scientist] | |||
Gastric bypass paper in Science Translational Medicine: | |||
[http://www.nytimes.com/2013/03/28/health/studies-focus-on-gut-bacteria-in-weight-loss.html?_r=0 NY Times] | |||
[http://news.harvard.edu/gazette/story/2013/03/major-weight-loss-tied-to-microbes/ Harvard Gazette] | |||
[http://www.latimes.com/health/boostershots/la-heb-gut-microbes-gastric-bypass-20130327,0,2926126.story LA Times] | |||
[http://health.usnews.com/health-news/news/articles/2013/03/27/gut-bacteria-may-be-key-to-gastric-bypass-effects-study US News] | |||
[http://www.sciencenews.org/view/generic/id/349233/description/Gut_microbes_may_be_behind_weight_loss_after_gastric_bypass Science News] | |||
[http://news.sciencemag.org/sciencenow/2013/03/gut-microbiomes-surgical-weight-.html Science] | |||
[http://www.newscientist.com/article/dn23324-gut-bacteria-swap-is-key-to-knifeless-gastric-bypass.html New Scientist] | |||
[http://www.the-scientist.com/?articles.view/articleNo/34866/title/Microbes-Affect-Weight-Loss/ Scientist] | |||
[http://www.nature.com/news/gut-microbe-swap-helps-mice-shed-weight-1.12688 Nature] | |||
[http://www.theglobeandmail.com/life/health-and-fitness/health-navigator/a-way-to-bypass-gastric-bypass-altering-gut-microbes-may-be-the-key/article10456842/ Globe and Mail] | |||
[http://www.scientificamerican.com/article.cfm?id=gut-microbe-swap-helps-weight-loss Scientific American] | |||
[http://www.technologyreview.com/news/512956/gut-microbes-could-help-us-lose-weight/ Tech Review] | |||
[http://www.bbc.co.uk/news/health-21965092 BBC] | |||
[http://www.cbsnews.com/8301-204_162-57576911/gut-bacteria-may-be-key-to-weight-loss/ CBS] | |||
[http://news.harvard.edu/gazette/story/2013/02/go-with-your-gut/ Harvard Gazette piece on our latest paper in Cell] | |||
[http://news.harvard.edu/gazette/story/2012/06/life-partner/ Harvard Gazette write-up on the Turnbaugh lab] | |||
[http://www.npr.org/blogs/thesalt/2013/02/20/172403779/calorie-counts-fatally-flawed-or-our-best-defense-against-pudge NPR on issues with calorie counts] | |||
[http://news.sciencemag.org/sciencenow/2013/02/have-we-been-miscounting-calorie.html ScienceNOW article on calorie labels] | [http://news.sciencemag.org/sciencenow/2013/02/have-we-been-miscounting-calorie.html ScienceNOW article on calorie labels] | ||
[http:// | [http://www.thecrimson.com/article/2013/2/21/microbes-personalized-medicine/ Harvard Crimson article on personalized medicine] | ||
[http://www.nature.com/nature/journal/v492/n7429/full/492366a.html Nature 2012 Editor's Choice], | [http://www.nature.com/nature/journal/v492/n7429/full/492366a.html Nature 2012 Editor's Choice], | ||
[http://www.biotechniques.com/news/Microdroplet-PCR-Takes-on-Population-Genomics/biotechniques-333443.html#.UBqLFo5gP8t Biotechniques piece on microfluidics], | [http://www.biotechniques.com/news/Microdroplet-PCR-Takes-on-Population-Genomics/biotechniques-333443.html#.UBqLFo5gP8t Biotechniques piece on microfluidics], | ||
[http://www.boston.com/whitecoatnotes/2012/06/13/human-microbiome-project-provides-census-thousands-microbes-that-live-and/IaliEtwLjSYiicNwhATrKM/story.html Human Microbiome Project], | [http://www.boston.com/whitecoatnotes/2012/06/13/human-microbiome-project-provides-census-thousands-microbes-that-live-and/IaliEtwLjSYiicNwhATrKM/story.html Human Microbiome Project], | ||
[http://www.washington.edu/news/articles/gut-microbe-networks-differ-from-norm-in-obese-people-systems-biology-approach-reveals-2 Systems Biology Paper out in PNAS], | [http://www.washington.edu/news/articles/gut-microbe-networks-differ-from-norm-in-obese-people-systems-biology-approach-reveals-2 Systems Biology Paper out in PNAS], | ||
| Line 37: | Line 81: | ||
==Outreach== | ==Outreach== | ||
[http:// | [http://outreach.mcb.harvard.edu/Microbiome/microbiome.html Microbiome Outreach Module], | ||
[http://www.youtube.com/watch?v=FMmN2qlhNII Richard Losick's iBio lecture], | |||
[http://academy.asm.org/index.php/faq-series/5122-humanmicrobiome ASM Microbiome FAQ] | |||
<br> | <br> | ||
<br> | <br> | ||
Latest revision as of 09:07, 10 January 2014
Inactivation of cardiac drugs by gut microbes
We are using cell culture, mass spectrometry, and studies in gnotobiotic mice (germ-free and colonized) to determine the mechanism of reduction of digoxin and other cardiac glycosides by members of the gut microbiota, and to determine whether or not it is possible to limit this reaction in vivo.
Single cell methods for analyzing microbial physiology and gene content
We are using flow cytometry and microfluidics to analyze complex microbial communities collected from the human gut at single cell resolution. These techniques allow us to determine the baseline physiology, activity, and gene content of gut microbes, and how these factors are shaped by clinically relevant perturbations, i.e. exposure to host-targeted drugs and antibiotics.
The role of diet and surgery in shaping the gut microbiome and host metabolic outcomes
We are studying how Roux-en-Y gastric bypass surgery re-shapes the gut microbiota, and to what degree these changes contribute to the metabolic outcomes of surgery (in collaboration with Lee Kaplan group at Mass General Hospital). We are also performing experiments on the role of diet in shaping gut microbial ecology.
Data
Data can be analyzed in MGRAST
Raw datasets are available from GEO and NCBI-SRA
See Gordon lab website for previous manuscript supporting information Supplementary Data
Selected Press Articles
Diet rapidly changes our gut microbes: Harvard Gazette Bloomberg New Scientist Science NPR KWUR National Geographic Chicago Tribune US News Scientist
Our recent paper on digoxin: Harvard Gazette Science News Naked Scientists Medical Daily
Links between obesity and cancer: Scientific American Science The Scientist
Gastric bypass paper in Science Translational Medicine: NY Times Harvard Gazette LA Times US News Science News Science New Scientist Scientist Nature Globe and Mail Scientific American Tech Review BBC CBS
Harvard Gazette piece on our latest paper in Cell Harvard Gazette write-up on the Turnbaugh lab
NPR on issues with calorie counts ScienceNOW article on calorie labels Harvard Crimson article on personalized medicine Nature 2012 Editor's Choice, Biotechniques piece on microfluidics, Human Microbiome Project, Systems Biology Paper out in PNAS, Science Podcast on detecting novel associations, Wired Microbiome Atlas, Nature News, National Public Radio spot 2009, Economist, Nature video about obesity, New York Times Fat Factors, Nature News 2006, National Public Radio spot 2006, Nature Podcast transcript 2006
Outreach
Microbiome Outreach Module,
Richard Losick's iBio lecture,
ASM Microbiome FAQ
