User:Adam B. Fisher

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George McArthur IV<br>
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Adam B. Fisher<br>
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[[Image:Afishinlab.jpg|thumb|225px|left|Adam Fisher candidly enjoying his morning coffee]]
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[[Image:Afishinlab.jpg|thumb|225px|left|Candidly counting some colonies]]
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'''''In nature hybrid species are usually sterile, but in science the reverse is often true.''''' <br />
'''''In nature hybrid species are usually sterile, but in science the reverse is often true.''''' <br />
'''''Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts.''''' <br />
'''''Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts.''''' <br />
- Francis Crick <br />
- Francis Crick <br />
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My research is focused on the development of genetically encoded molecular devices to control the expression and activity of metabolic pathways in microbes.  This is made possible largely by significant advances in computational, systems and synthetic biology.  I earned a BS in 2008 from the University of Virginia where I studied music, chemical engineering and biology and was mentored by Erik Fernandez (chemical engineering) and Jason Papin (biomedical engineering).  I carried out my graduate research with Travis Bayer (synthetic biology) at Imperial College London, where I was a Whitaker International Fellow, and with Steve Fong at Virginia Commonwealth University (chemical engineering) where I earned my PhD in 2013. In addition to my research, I develop material for engineering and biotechnology curricula. My research interests include:
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'''''I am very comfortable with the idea that we can override biology with free will.''''' <br />
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- Richard Dawkins<br />
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As a researcher, I am broadly interested in integrating approaches and technologies found in synthetic and systems biology, metabolic engineering, chemical biology and quantitative biology to facilitate microbial engineering. At Virginia Tech, I had my first exposure to these emergent fields while working as an undergraduate to build out and characterize a bi-stable genetic toggle switch. Subsequently, I joined the lab of [[Fong|Dr. Stephen Fong]] at Virginia Commonwealth University endeavoring toward a PhD in Integrative Life Sciences. Currently, I am involved in projects revolving around ''ex vivo'' approaches for cloning and synthetic biology, a synthetic biomolecular delivery system and a cost analysis for the interpretation of genome-scale models. My overall research interests include:
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*Orthogonal gene expression
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*Artificial gene networks
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*Cell Free Systems
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*Synthetic gene assembly
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*Protein engineering
*Synthetic metagenomics
*Synthetic metagenomics
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*Genome organization, refactoring & design
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*Genome-scale metabolic models
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*Metabolic, organellar & enzyme engineering
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*Statistical models of biological sequences
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*Genome-scale, single-cell characterization
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*Engineered microbial consortia
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==Education & Training==
==Education & Training==
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'''Imperial College London ·''' ''London, UK'' '''·''' 2011 — 2012
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'''Virginia Commonwealth University ·''' ''Richmond, VA'' '''·''' 2011 2014
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*Whitaker International Fellow '''·''' Bioengineering
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*Ph.D. '''·''' Integrative Life Sciences
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**Advised by Travis S. Bayer
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'''Virginia Commonwealth University ·''' ''Richmond, VA'' '''·''' 2008 2013
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*Ph.D. '''·''' Chemical and Biological Engineering
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**Advised by Stephen S. Fong
**Advised by Stephen S. Fong
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*M.S. '''·''' Chemical Engineering
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'''Virginia Tech ·''' ''Blacksburg, VA'' '''·''' 2007 2011
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*B.S. '''·''' Biological Sciences
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'''University of Virginia ·''' ''Charlottesville, VA'' '''·''' 2002 2008
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**Concentration in Microbiology & Immunology
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*B.S. '''·''' Chemical Engineering
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*Minor '''·''' Business
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**Advised by Erik J. Fernandez and Jason A. Papin
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*B.A. '''·''' Music
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*Minor '''·''' Biology
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==Publications==
==Publications==
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*G.H. McArthur 4th and S.S. Fong. (2013). Modulating gene expression with designed UP elements. In preparation.
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*'''Fisher, A. B.''', Canfield, Z. B., Hayward, L. C. & Fong, S. ex vivo DNA assembly. Fronteirs in Bioengineering and Biotechnology (2013). doi:10.3389/fbioe.2013.00012 <br/>
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*M. Montague, G.H. McArthur 4th, C.S. Cockell, J. Held, W. Marshall, L.A. Sherman, N. Wang, W.L. Nicholoson, D. Tarjan and J. Cumbers. (2012). [http://online.liebertpub.com/doi/abs/10.1089/ast.2012.0829 The role of synthetic biology for in situ resource utilization (ISRU)]. ''Astrobiology''.
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*Vanee N, '''Fisher AB''', Fong SS. “Evolutionary Engineering for Industrial Microbiology”. Subcellular Biochemistry: Reprogramming Microbial Metabolic Pathways (New York: Springer Verlag, 2012), Vol. 64.
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*G.H. McArthur 4th and S.S. Fong. (2010). [http://www.hindawi.com/journals/jbb/2010/459760.abs.html Toward engineering synthetic microbial metabolism]. ''J. Biomed. Biotechnol.'' doi:10.1155/2010/459760.
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==Presentations==
==Presentations==
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*Poster - Predictable gene expression using extended promoters and orthogonal cellular machinery, Cell factories and Biosustainability. Favrholm, Copenhagen, DK, 5-8 May 2013
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*Poster - DNA Assembly for free: using cellular lysates to decrease cloning costs, Synthetic Biology 6.0. Imperial College of London, UK 9-12 July 2013
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*Poster - The development of a genetically encoded, function-based taxol biosensor, Metabolic Engineering IX. Biarritz, FR, 3-7 June 2012
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*Talk/Poster - Cyanobacteria: A sustainable manufacturing platform, iGEM Americas Regional Jamboree. Indiana University Purdue University Indianapolis, Indianapolis, IN, 8-10 October 2011
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*Poster - An orthogonal transcription platform for fine-tuning gene expression, Synthetic Biology 5.0. Stanford University, Stanford, CA, 15-17 June 2011
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*Poster (invited) - A synthetic platform for controlling gene expression, Workshop: What are the potential roles of synthetic biology in NASA's mission?, 30-31 October 2010, NASA Ames Center, Moffett Field, CA
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*Poster - Modulating gene expression in ''Escherichia coli'' with synthetic UP elements, BIOFAB 2010 Community Meeting, 19-20 July 2010, Emeryville, CA
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*Poster - Modulating gene expression in ''Escherichia coli'' with synthetic UP elements, ASM 2010, 23-27 May 2010, San Diego, CA
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*Poster - ''Chlamydomonas reinhardtii'' as a photosynthetic cellular chassis and power supply for synthetic biological systems, BioSysBio 2009, 23-25 March 2009, Cambridge University, Cambridge, UK
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*Poster - ''Chlamydomonas reinhardtii'' as a platform for the direct photosynthesis of advanced biofuels, Institute of Biological Engineering 2009 annual meeting, 19-22 March 2009, Santa Clara, CA
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*Poster - A bottom-up approach to synthetic biology education: From iGEM teams to undergraduate curricula, Synthetic Biology 4.0, 10-12 October 2008, HKUST, Hong Kong, China
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*Talk - [http://tv.theiet.org/technology/electronics/1199.cfm The Virginia Genetically Engineered Machine Team], BioSysBio 2008, 20-22 April 2008, Imperial College London, London, UK
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*Poster - Harvesting cellulose and light to power butanol biosynthesis: A synthetic biology approach to metabolic engineering, Institute of Biological Engineering 2008 annual meeting, 6-9 March 2008, Chapel Hill, NC
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*Talk/poster - Harvesting cellulose and light to power butanol biosynthesis: A synthetic biology approach to metabolic engineering, iGEM 2007, 3-4 November 2007, MIT, Cambridge, MA
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==Intellectual Property==
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*'''Fisher AB''', Brooks JP, Fong SS (2013) Cellular Strain Design Using Large-Scale Cost Analysis (Virginia Commonwealth University)
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Revision as of 16:49, 15 November 2013

·

Adam B. Fisher

Candidly counting some colonies
Candidly counting some colonies

In nature hybrid species are usually sterile, but in science the reverse is often true.
Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts.
- Francis Crick


What I cannot create, I cannot understand.
- Richard Feynman



I am very comfortable with the idea that we can override biology with free will.
- Richard Dawkins



As a researcher, I am broadly interested in integrating approaches and technologies found in synthetic and systems biology, metabolic engineering, chemical biology and quantitative biology to facilitate microbial engineering. At Virginia Tech, I had my first exposure to these emergent fields while working as an undergraduate to build out and characterize a bi-stable genetic toggle switch. Subsequently, I joined the lab of Dr. Stephen Fong at Virginia Commonwealth University endeavoring toward a PhD in Integrative Life Sciences. Currently, I am involved in projects revolving around ex vivo approaches for cloning and synthetic biology, a synthetic biomolecular delivery system and a cost analysis for the interpretation of genome-scale models. My overall research interests include:

  • Cell Free Systems
  • Synthetic gene assembly
  • Protein engineering
  • Synthetic metagenomics
  • Genome-scale metabolic models
  • Statistical models of biological sequences
  • Engineered microbial consortia


Education & Training

Virginia Commonwealth University · Richmond, VA · 2011 — 2014

  • Ph.D. · Integrative Life Sciences
    • Advised by Stephen S. Fong

Virginia Tech · Blacksburg, VA · 2007 — 2011

  • B.S. · Biological Sciences
    • Concentration in Microbiology & Immunology
  • Minor · Business


Publications

  • Fisher, A. B., Canfield, Z. B., Hayward, L. C. & Fong, S. ex vivo DNA assembly. Fronteirs in Bioengineering and Biotechnology (2013). doi:10.3389/fbioe.2013.00012
  • Vanee N, Fisher AB, Fong SS. “Evolutionary Engineering for Industrial Microbiology”. Subcellular Biochemistry: Reprogramming Microbial Metabolic Pathways (New York: Springer Verlag, 2012), Vol. 64.


Presentations

  • Poster - DNA Assembly for free: using cellular lysates to decrease cloning costs, Synthetic Biology 6.0. Imperial College of London, UK 9-12 July 2013
  • Talk/Poster - Cyanobacteria: A sustainable manufacturing platform, iGEM Americas Regional Jamboree. Indiana University Purdue University Indianapolis, Indianapolis, IN, 8-10 October 2011


Intellectual Property

  • Fisher AB, Brooks JP, Fong SS (2013) Cellular Strain Design Using Large-Scale Cost Analysis (Virginia Commonwealth University)



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