User:Adam B. Fisher: Difference between revisions

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Adam B. Fisher<br>
Adam B. Fisher<br>
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[[Image:Afishinlab.jpg|thumb|225px|left|Adam Fisher candidly enjoying his morning coffee]]
[[Image:Afishinlab.jpg|thumb|225px|left|Candidly counting some colonies]]
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'''''In nature hybrid species are usually sterile, but in science the reverse is often true.''''' <br />
'''''In nature hybrid species are usually sterile, but in science the reverse is often true.''''' <br />
'''''Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts.''''' <br />
'''''Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts.''''' <br />
- Francis Crick <br />
- Francis Crick <br />
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As a researcher, I am broadly interested in integrating approaches and technologies found in synthetic and systems biology, metabolic engineering, bioinformatics and quantitative biology to facilitate microbial engineering. As an undergraduate at Virginia Tech I majored in Biology, concentrating in Microbiology and Immunology, where I had my first exposure to these emergent fields while working as an undergraduate researcher in the laboratory of [[Jean_Peccoud|Dr. Jean Peccoud]]. I worked alongside [[Matthew_W_Lux|Matthew Lux]] to build out and characterize a bi-stable genetic toggle switch. Subsequently, I joined the [[Fong]] lab at Virginia Commonwealth where I began my PhD in Integrative Life Sciences. My research interests include:
As a researcher, I am broadly interested in integrating approaches and technologies found in synthetic and systems biology, metabolic engineering, chemical biology and quantitative biology to facilitate microbial engineering. At Virginia Tech, I had my first exposure to these emergent fields while working as an undergraduate to build out and characterize a bi-stable genetic toggle switch. Subsequently, I joined the lab of [[Fong|Dr. Stephen Fong]] at Virginia Commonwealth University endeavoring toward a PhD in Integrative Life Sciences. Currently, I am involved in projects involving ''ex vivo'' approaches for cloning and synthetic biology, a synthetic biomolecular delivery system and a cost analysis for the interpretation of genome-scale models. My research interests include:
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*Orthogonal gene expression
*Cell-Free and ''ex vivo'' approaches to molecular biology and biotechnology
*Artificial gene networks
*Genome engineering and high-throughput cloning
*Global physiology and single-cell characterization
*Development of engineering platforms for exotic microorganisms
*Engineered microbial consortia and microbiota
*Synthetic metagenomics
*Synthetic metagenomics
*Genome organization, refactoring & design
*Protein engineering
*Metabolic, organellar & enzyme engineering
*Construction and simulation of genome-scale models
*Genome-scale, single-cell characterization
*Statistical modeling of biological sequences
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==Education & Training==
==Education & Training==
'''Imperial College London ·''' ''London, UK'' '''·''' 2011 — 2012
'''Virginia Commonwealth University ·''' ''Richmond, VA'' '''·''' 2011 — 2014
*Whitaker International Fellow '''·''' Bioengineering
*Ph.D. '''·''' Integrative Life Sciences
**Advised by Travis S. Bayer
 
'''Virginia Commonwealth University ·''' ''Richmond, VA'' '''·''' 2008 — 2013
*Ph.D. '''·''' Chemical and Biological Engineering
**Advised by Stephen S. Fong
**Advised by Stephen S. Fong
*M.S. '''·''' Chemical Engineering
'''Virginia Tech ·''' ''Blacksburg, VA'' '''·''' 2007 — 2011
 
*B.S. '''·''' Biological Sciences
'''University of Virginia ·''' ''Charlottesville, VA'' '''·''' 2002 — 2008
**Concentration in Microbiology & Immunology
*B.S. '''·''' Chemical Engineering
*Minor '''·''' Business
**Advised by Erik J. Fernandez and Jason A. Papin
*B.A. '''·''' Music
*Minor '''·''' Biology
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==Publications==
==Publications==
*G.H. McArthur 4th and S.S. Fong. (2013). Modulating gene expression with designed UP elements. In preparation.
*'''Fisher, A. B.''', Canfield, Z. B., Hayward, L. C. & Fong, S. "Ex vivo DNA assembly". Frontiers in Bioengineering and Biotechnology (2013). doi:10.3389/fbioe.2013.00012 <br/>
*M. Montague, G.H. McArthur 4th, C.S. Cockell, J. Held, W. Marshall, L.A. Sherman, N. Wang, W.L. Nicholoson, D. Tarjan and J. Cumbers. (2012). [http://online.liebertpub.com/doi/abs/10.1089/ast.2012.0829 The role of synthetic biology for in situ resource utilization (ISRU)]. ''Astrobiology''.
*Vanee N, '''Fisher AB''', Fong SS. “Evolutionary Engineering for Industrial Microbiology”. Subcellular Biochemistry: Reprogramming Microbial Metabolic Pathways (New York: Springer Verlag, 2012), Vol. 64.
*G.H. McArthur 4th and S.S. Fong. (2010). [http://www.hindawi.com/journals/jbb/2010/459760.abs.html Toward engineering synthetic microbial metabolism]. ''J. Biomed. Biotechnol.'' doi:10.1155/2010/459760.
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==Presentations==
==Presentations==
*Poster - Predictable gene expression using extended promoters and orthogonal cellular machinery, Cell factories and Biosustainability. Favrholm, Copenhagen, DK, 5-8 May 2013
*Poster - DNA Assembly for free: using cellular lysates to decrease cloning costs, Synthetic Biology 6.0. Imperial College of London, UK 9-12 July 2013
*Poster - The development of a genetically encoded, function-based taxol biosensor, Metabolic Engineering IX. Biarritz, FR, 3-7 June 2012
*Talk/Poster - Cyanobacteria: A sustainable manufacturing platform, iGEM Americas Regional Jamboree. Indiana University Purdue University Indianapolis, Indianapolis, IN, 8-10 October 2011
*Poster - An orthogonal transcription platform for fine-tuning gene expression, Synthetic Biology 5.0. Stanford University, Stanford, CA, 15-17 June 2011
*Poster (invited) - A synthetic platform for controlling gene expression, Workshop: What are the potential roles of synthetic biology in NASA's mission?, 30-31 October 2010, NASA Ames Center, Moffett Field, CA
*Poster - Modulating gene expression in ''Escherichia coli'' with synthetic UP elements, BIOFAB 2010 Community Meeting, 19-20 July 2010, Emeryville, CA
*Poster - Modulating gene expression in ''Escherichia coli'' with synthetic UP elements, ASM 2010, 23-27 May 2010, San Diego, CA
*Poster - ''Chlamydomonas reinhardtii'' as a photosynthetic cellular chassis and power supply for synthetic biological systems, BioSysBio 2009, 23-25 March 2009, Cambridge University, Cambridge, UK
*Poster - ''Chlamydomonas reinhardtii'' as a platform for the direct photosynthesis of advanced biofuels, Institute of Biological Engineering 2009 annual meeting, 19-22 March 2009, Santa Clara, CA
*Poster - A bottom-up approach to synthetic biology education: From iGEM teams to undergraduate curricula, Synthetic Biology 4.0, 10-12 October 2008, HKUST, Hong Kong, China
*Talk - [http://tv.theiet.org/technology/electronics/1199.cfm The Virginia Genetically Engineered Machine Team], BioSysBio 2008, 20-22 April 2008, Imperial College London, London, UK
*Poster - Harvesting cellulose and light to power butanol biosynthesis: A synthetic biology approach to metabolic engineering, Institute of Biological Engineering 2008 annual meeting, 6-9 March 2008, Chapel Hill, NC
*Talk/poster - Harvesting cellulose and light to power butanol biosynthesis: A synthetic biology approach to metabolic engineering, iGEM 2007, 3-4 November 2007, MIT, Cambridge, MA
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==Intellectual Property==
*'''Fisher AB''', Brooks JP, Fong SS (2013) Cellular Strain Design Using Large-Scale Cost Analysis (Virginia Commonwealth University)
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Revision as of 09:56, 6 May 2014

·

Adam B. Fisher

Candidly counting some colonies

In nature hybrid species are usually sterile, but in science the reverse is often true.
Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts.
- Francis Crick


What I cannot create, I cannot understand.
- Richard Feynman



I am very comfortable with the idea that we can override biology with free will.
- Richard Dawkins



As a researcher, I am broadly interested in integrating approaches and technologies found in synthetic and systems biology, metabolic engineering, chemical biology and quantitative biology to facilitate microbial engineering. At Virginia Tech, I had my first exposure to these emergent fields while working as an undergraduate to build out and characterize a bi-stable genetic toggle switch. Subsequently, I joined the lab of Dr. Stephen Fong at Virginia Commonwealth University endeavoring toward a PhD in Integrative Life Sciences. Currently, I am involved in projects involving ex vivo approaches for cloning and synthetic biology, a synthetic biomolecular delivery system and a cost analysis for the interpretation of genome-scale models. My research interests include:

  • Cell-Free and ex vivo approaches to molecular biology and biotechnology
  • Genome engineering and high-throughput cloning
  • Global physiology and single-cell characterization
  • Development of engineering platforms for exotic microorganisms
  • Engineered microbial consortia and microbiota
  • Synthetic metagenomics
  • Protein engineering
  • Construction and simulation of genome-scale models
  • Statistical modeling of biological sequences


Education & Training

Virginia Commonwealth University · Richmond, VA · 2011 — 2014

  • Ph.D. · Integrative Life Sciences
    • Advised by Stephen S. Fong

Virginia Tech · Blacksburg, VA · 2007 — 2011

  • B.S. · Biological Sciences
    • Concentration in Microbiology & Immunology
  • Minor · Business


Publications

  • Fisher, A. B., Canfield, Z. B., Hayward, L. C. & Fong, S. "Ex vivo DNA assembly". Frontiers in Bioengineering and Biotechnology (2013). doi:10.3389/fbioe.2013.00012
  • Vanee N, Fisher AB, Fong SS. “Evolutionary Engineering for Industrial Microbiology”. Subcellular Biochemistry: Reprogramming Microbial Metabolic Pathways (New York: Springer Verlag, 2012), Vol. 64.


Presentations

  • Poster - DNA Assembly for free: using cellular lysates to decrease cloning costs, Synthetic Biology 6.0. Imperial College of London, UK 9-12 July 2013
  • Talk/Poster - Cyanobacteria: A sustainable manufacturing platform, iGEM Americas Regional Jamboree. Indiana University Purdue University Indianapolis, Indianapolis, IN, 8-10 October 2011


Intellectual Property

  • Fisher AB, Brooks JP, Fong SS (2013) Cellular Strain Design Using Large-Scale Cost Analysis (Virginia Commonwealth University)



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