User:Allison K. Alix/Notebook/CHEM-581/2013/01/30: Difference between revisions
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==Description== | ==Description== | ||
Currently the oral delivery of insulin is not possible | Currently the oral delivery of insulin is not possible due to it's degradation in the stomach before reaching the bloodstream. This project will employ a system comprised of a hydrogel core in which insulin will be distributed(to begin synthesis today) which will ultimately be coated by a lipid bilayer. The purpose for the lipid bilayer is for the system to successfully pass through the stomach acid (lipids are not digested until reaching the small intestine) at which point the hydrogel will be exposed and the insulin will be absorbed into the blood. | ||
==Procedure== | ==Procedure== |
Revision as of 07:55, 6 February 2013
Experimental Chemistry | <html><img src="/images/9/94/Report.png" border="0" /></html> Main project page <html><img src="/images/c/c3/Resultset_previous.png" border="0" /></html>Previous entry<html> </html>Next entry<html><img src="/images/5/5c/Resultset_next.png" border="0" /></html> |
ObjectiveBegin hydrogel formation using freeze-thaw method for the design of a system that allows for the oral delivery of insulin. DescriptionCurrently the oral delivery of insulin is not possible due to it's degradation in the stomach before reaching the bloodstream. This project will employ a system comprised of a hydrogel core in which insulin will be distributed(to begin synthesis today) which will ultimately be coated by a lipid bilayer. The purpose for the lipid bilayer is for the system to successfully pass through the stomach acid (lipids are not digested until reaching the small intestine) at which point the hydrogel will be exposed and the insulin will be absorbed into the blood. ProcedureDissolve 0.5g PVOH of the following molecular weights in 6mL of H2O @ 95°C : a) 22,000 (MP Biomedicals) b) 89,000-98,000 99+% hydrolysis(Aldrich Chemistry) c) 130,000 99+% hydrolysis(Aldrich Chemistry) d) 146,000-186,000 99+% hydrolysis(Aldrich Chemistry)
Data
Referenceshttp://jtc.sagepub.com/content/early/2011/12/26/0892705711430857.full.pdf+html http://www.kirj.ee/public/proceedings_pdf/2009/issue_1/proc-2009-1-63-66.pdf
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