User:Andor J Kiss
From OpenWetWare
Contact Info
- Visiting Assistant Professor
- Department of Zoology
- 194 Pearson Hall
- Miami University
- Oxford, OH 45056
I work in collaboration with the Laboratory for Ecophysiological Cryobiology at Miami University. I am also a member of the Center for Visual Sciences at Miami University.
Education
- 2005, PhD, University of Illinois at Urbana-Champaign
- 1999, MSc, University of Western Ontario
- 1994, BSc, University of Victoria
Research interests
- My research interests are in the adaptive and evolutionary mechanism of animals. More specifically I am interested in vertebrate animals and their adaptation to extreme cold and heat, and how their physiological systems have evolved to allow them to exploit such niches. The model system that I have been using is that of the proteins in the eye lens. The proteins are called “crystallins” and play an important role in light refraction. Most vertebrates (excluding some birds) have three kinds of crystallins; alpha (a), beta (b) and gamma (g). Alpha crystallin is also a type of small heat shock (sHSP) protein and comes in at least two flavours (isoforms). One of these a isoforms can be found widely expressed outside the eye lens and has important roles as a stress protein in a number of tissues. The b and g crystallins are part of the same super-gene family, but presently there are no known non-refractive structure/function roles. Adaptation of ectothermic vertebrate lenses to cold is of interest to me as means of modelling not only lens cataracts, but to modelling globular protein stability. Lens cataract is a rare example of a system that allows investigation into stability of globular non-enzymatic proteins and protein systems.
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Publications
- Goldbeter A and Koshland DE Jr. An amplified sensitivity arising from covalent modification in biological systems. Proc Natl Acad Sci U S A. 1981 Nov;78(11):6840-4. DOI:10.1073/pnas.78.11.6840 |
- JACOB F and MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318-56. DOI:10.1016/s0022-2836(61)80072-7 |
leave a comment about a paper here
- ISBN:0879697164
