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| Anthony is a second year undergraduate student part of Imperial's 2007 iGEM team | | Anthony is a second year undergraduate student part of Imperial's 2007 iGEM team |
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| | ==My iGEM Experience== |
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| | *Modeling : Deterministic Modeling used to look for emerging properties (link to new modeling & data analysis wiki) |
| | *Data Analysis : Curve Fitting to extract parameters (link to modeling & data analysis wiki) |
| | *PR : Motif Design that transcends wiki, t-shirts, presentation and our poster |
| | *Website Design : |
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| ==MESSING AROUND== | | ==MESSING AROUND== |
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| [[User : Anthony Lazzaro / SANDBOX | MY SANDBOX ]] | | [[User : Anthony Lazzaro / SANDBOX | MY SANDBOX ]] |
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| ==Milestones for PR ==
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| ==Imperial's 2007 iGEM Project Definition==
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| ===VesoCops - Imperial College iGEM 2007 Team ** Work in Progress We're making VesoCop!!! **===
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| [[image:IC07_biofilm.png|thumb|right|300px|Infector Detector]]
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| The Imperial College iGEM 2007 team consists of ten undergraduate bioengineering and bioscience students. This year, we are engineering '''VesoCops''', biological systems that report the presence of nasty bacteria. Under the Cell-Free Intelligence (CFI), we have two divisions. First, a surveillance team called '''Cell By Date''' that determines when food is spoilt more accurately than printed sell by dates. It exploits the thermal dependence of the rate of expression of a simple reporter system. The second division consists of an undercover team - '''Infector Detector''', which detects biofilms that are antibiotic-resistant and a major source of infection in hospitals. This system makes use of Lux quorum sensing to eavesdrop on the communication between biofilm-forming bacteria.
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| [[image:IC07_cellbydate.png|thumb|left|320px|Cell By Date]]
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| Our contributions to the synthetic biology community will be the characterization of '''Cell-Free Chassis''', the common platform on which Cell By Date and Infector Detector will be built. The cell-free approach is particularly useful for VesoCops to operate in the food and medical industries. We believe this new chassis will unlock fresh potential in simple constructs. Our project strategy is based on the '''Engineering Cycle''', of which we have completed specification and design of the systems. We are starting on modelling and implementation and we aim to test our final constructs in the new chassis. By the end of the summer, the VesoCops will be combat-ready.
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| -----------------------------------------------
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| '''The Story:'''
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| We approach synthetic biology with a view of making bacteria help us. The media is rife with stories of Synthetic Biology being a threat as it could make the next super weapon and how bacteria are bad and make us sick. We want bacteria that serve us, to inspire confidence in Synthetic biology, and that protect us from these daily threats to show that bacteria can be well behaved. The idea of to protect & serve leads us to the idea of a cop , a bactocop of you will.
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| '''The Project:'''
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| BactoCops, Imperial College’s iGEM 2007 project, delivers a new breed of grime fighting officers. The current state of affairs is that only the run of the mill BactoCops are in operation, the make up the BAPD is you will. These BactoCops can’t do a lot because they use E.Coli as a chassis – they can’t be near open wounds or near our food for example. We are focusing on bringing a new type of agency to the BactoCop world consisting of SuperBactocops – we call it the CIA : the Cell Free Intelligence Agency. This new agency has unbelievable potential and to demonstrate this we have two amazing teams. Firstly, a surveillance team called '''Cell By Date''' that determines when food is spoilt more accurately than printed sell by dates. It exploits the thermal dependence of the rate of expression of a simple reporter system. Our second team goes undercover, codename - '''Infector Detector''', it detects biofilms that are antibiotic-resistant and a major source of infection in hospitals. This system makes use of Lux quorum sensing to eavesdrop on the communication between biofilm-forming bacteria.
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| <br>
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| {| border="0" width="100% align="center"
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| | [[image:IC07_biofilm.png|thumb|right|300px|Infector Detector]]
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| [[image:IC07_cellbydate.png|thumb|left|320px|Cell By Date]]
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| |}
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| Our contributions to the synthetic biology community will be the characterization of '''Cell-Free Chassis''', the common platform on which Cell By Date and Infector Detector will be built. The cell-free approach is particularly useful for BactoCops to operate in the food and medical industries. This is because living, replicating engineered bacteria pose major health risks. We believe this new chassis will unlock fresh potential in simple constructs.
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| '''The Progress:'''
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| Our project strategy is based on the '''Engineering Cycle''', of which we have completed specification and design of the systems. We are starting on modelling and implementation and we aim to test our final constructs in the new chassis. By the end of the summer, the BactoCops will be combat-ready.
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| Re-Revised Project dEscription corrections:
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| 1. Remove BactoCops
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| 2. Make Biofilm Detector Picture look more medical
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| My Project Description Corrections:
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| 1. Story needs to be re-written it paints syn bioin a very negative light
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| 2. Cell by date doesn't report the presence of nasty bacteria
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| 3. BactoCops is misleading because we are not using bacteria
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| Possible way forward is to extend the RoboCop / VesoCop Idea
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| Story:
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| Current state of affairs is that syn. Bio has made tremendous progress in terms of making Bacteria Do wonderful things for us protecting us in Variety of situations, they behave like the police men around us they are if you will BactoCops. But these bactocops can't do everything, with E.Coli as a Chassis they are ineffective in certain situation. There is a need now for a new breed of BactoCop that can go to these places, further than any BactoCop before him : we can him VesoCop
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