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[[Image: | [[Image:drexler_2011.jpg|frame|right|Berthold Drexler]] | ||
Welcome to my homepage, hosted by OpenWetWare<br> | Welcome to my homepage, hosted by OpenWetWare<br> | ||
I'm a | I'm a senior physician (cunsultant) at the [http://www.medizin.uni-tuebingen.de/Patienten/Anaesthesiologie%20und%20Intensivmedizin-p-196.html Department of Anaesthesiology and Intensive Care, University Hospital Tübingen], [http://www.uni-tuebingen.de Eberhard Karls University Tübingen], Germany and member of the [[Experimental_Anaesthesiology_Antkowiak_Lab | Antkowiak Lab]]<br> | ||
'''Berthold Drexler'''<br> | |||
[[Experimental_Anaesthesiology_Antkowiak_Lab | Section for Experimental Anaesthesiology]]<br> | |||
Department of Anaesthesiology and Intensive Care, University Hospital Tuebingen<br> | Department of Anaesthesiology and Intensive Care, University Hospital Tuebingen<br> | ||
Waldhoernlestr. 22, 72072 Tuebingen, Germany<br> | |||
[[Special:Emailuser/Berthold Drexler|Email me through OpenWetWare]]<br> | |||
email: berthold DOT drexler AT uni MINUS tuebingen DOT de<br> | email: berthold DOT drexler AT uni MINUS tuebingen DOT de<br> | ||
skype: drexlerb<br> | skype: drexlerb<br> | ||
==Education== | ==Education== | ||
* [http://www. | * ATLS®-Provider [http://www.facs.org/trauma/atls/about.html ATLS] | ||
* | * Post Doctoral Fellowship: Experimental Anaesthesiology, Head: Prof. Dr. Bernd Antkowiak | ||
* | * [http://www.esicm.org/education/european-diploma European Diploma in Intensive Care] 11/2010 | ||
* Board Certification Intensive Care Medicine 11/2008 | |||
* [http://www.esahq.org/education/edaic European Diploma in Anaesthesiology] 10/2007 | |||
* Board Certification Anaesthesiology 05/2007 | |||
* Internship/Residency: University Hospital Tübingen, Germany, [http://www.medizin.uni-tuebingen.de/Patienten/Anaesthesiologie%20und%20Intensivmedizin-p-196.html Department of Anaesthesiology and Intensive Care], Head: Prof. Dr. Klaus Unertl | * Internship/Residency: University Hospital Tübingen, Germany, [http://www.medizin.uni-tuebingen.de/Patienten/Anaesthesiologie%20und%20Intensivmedizin-p-196.html Department of Anaesthesiology and Intensive Care], Head: Prof. Dr. Klaus Unertl | ||
* | * Doctoral Thesis (MD), Albert-Ludwigs-University Freiburg, [http://www.herzzentrum.de/Home/Landing_Kardiologie_UHZFR Cardiology], Supervisor: Prof. Dr. Christian Holubarsch | ||
* [http://www. | * Final Year: Internal Medicine [http://www.spitaluster.ch Spital Uster, CH]; Heart Surgery [http://capegateway.gov.za/gsh Groote Schuur Hospital, SA]; Anaesthesiology [http://www.uniklinik-freiburg.de/anaesthesie/live/index.html University Hospital Freiburg] | ||
* [http://www.uni-freiburg.de Albert-Ludwigs-University], Medical School, Freiburg, Germany | |||
* | |||
==Research interests== | ==Research interests== | ||
'''Mechanisms of Anaesthesia - GABA<sub>A</sub> Receptor Subtypes''' - Electrophysiology - Cortex - Organotypic Slice Cultures | '''Mechanisms of Anaesthesia - GABA<sub>A</sub> Receptor Subtypes''' - Electrophysiology - Cortex - Organotypic Slice Cultures | ||
==Memberships== | ==Memberships== | ||
* Associate Faculty Member of the [http://f1000.com/prime Faculty of 1000] | |||
* [http://www.euroanesthesia.org European Society of Anaesthesiology] | |||
* [http://www.esicm.org/ European Society of Intensive Care Medicine] | |||
* [http://www.dgai.de German Society for Anesthesiology and Intensive Care Medicine (DGAI)] | * [http://www.dgai.de German Society for Anesthesiology and Intensive Care Medicine (DGAI)] | ||
* Selected mentee of the [http://www.wakwin.de Mentoring Program for Junior Investigators (DGAI)] | * Selected mentee of the [http://www.wakwin.de Mentoring Program for Junior Investigators (DGAI)] | ||
* [http://www.neuroanaesthesie-online.de Working Committee Neuroanaesthesia (DGAI) | * [http://www.neuroanaesthesie-online.de/index1.html Working Committee Neuroanaesthesia (DGAI)] | ||
==Publications== | ==Selected Publications== | ||
* | * Drexler B, Kreuzer M, Jordan D, Antkowiak B, Schneider G. Sevoflurane-induced loss of consciousness is paralleled by a prominent modification of neural activity during cortical down-states. Neurosci Letters 548:149-54; 2013 [http://www.sciencedirect.com/science/article/pii/S0304394013004758 abstract] | ||
* Drexler B, Zinser S, Huang S, Poe MM, Rudolph U, Cook JM, Antkowiak B. Enhancing the function of alpha5-subunit-containing GABA(A) receptors promotes action potential firing of neocortical neurons during up-states. Eur J Pharmacol. 703(1-3): 18-24; 2013 [http://www.sciencedirect.com/science/article/pii/S0014299913000496 abstract] | |||
* Drexler B, Antkowiak B, Engin E, Rudolph U: Identification and characterization of anesthetic targets by mouse molecular genetics approaches, Canadian Journal of Anesthesia 58: 178-190; 2011 [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330822/ PMC] | |||
* Drexler B, Hentschke H, Antkowiak B, Grasshoff C: Organotypic Cultures as Tools for Testing Neuroactive Drugs - Link Between ''In-Vitro'' and ''In-Vivo'' Experiments, Current Medicinal Chemistry 17(36): 4538-4550; 2010 [http://www.ncbi.nlm.nih.gov/pubmed/21062252 abstract] | |||
* Drexler B, Zinser S, Hentschke H, Antkowiak B: [http://www.anesthesia-analgesia.org/content/111/6/1394.long Diazepam decreases action potential firing of neocortical neurons via two distinct mechanisms] Anesthesia & Analgesia 111(6):1394-1399; 2010 | |||
* Drexler B, Jurd R, Rudolph U, Antkowiak B: Distinct actions of etomidate and propofol at β3-containing γ-aminobutyric acid type A receptors, Neuropharmacology 57 (4): 446-55, 2009 [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0C-4WKK1VJ-2&_user=10&_coverDate=09%2F30%2F2009&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fc9fbdf2f955f51b6bd855d8d3671a4f&searchtype=a abstract] and [http://f1000.com/1480964 F1000] | |||
* Drexler B, Jurd R, Rudolph U, Antkowiak B: [http://journals.lww.com/anesthesiology/Fulltext/2006/08000/Dual_Actions_of_Enflurane_on_Postsynaptic_Currents.12.aspx Dual Actions of Enflurane on Postsynaptic Currents Abolished by the γ-Aminobutyric Acid Type A Receptor β3(N265M) Point Mutation] Anesthesiology 105: 297-304; 2006 | |||
* Drexler B, Roether CL, Jurd R, Rudolph U, Antkowiak B: [http://journals.lww.com/anesthesiology/Fulltext/2005/02000/Opposing_Actions_of_Etomidate_on_Cortical_Theta.17.aspx Opposing Actions of Etomidate on Cortical Theta Oscillations Are Mediated by Different γ-Aminobutyric Acid Type A receptor subtypes] Anesthesiology 102: 346-52; 2005 | * Drexler B, Roether CL, Jurd R, Rudolph U, Antkowiak B: [http://journals.lww.com/anesthesiology/Fulltext/2005/02000/Opposing_Actions_of_Etomidate_on_Cortical_Theta.17.aspx Opposing Actions of Etomidate on Cortical Theta Oscillations Are Mediated by Different γ-Aminobutyric Acid Type A receptor subtypes] Anesthesiology 102: 346-52; 2005 | ||
* Drexler B, | * Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt K, Ledermann B, Antkowiak B, Rudolph U: [http://www.fasebj.org/cgi/reprint/02-0611fjev1 General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor β3 subunit] FASEB J 17: 250-252; 2003 | ||
==Links== | ==Links== | ||
*[[Theilmeier Lab]] | *[[Theilmeier Lab]] | ||
*[[Organprotektion Lab]] | *[[Organprotektion Lab]] | ||
Revision as of 04:28, 11 December 2013
Welcome to my homepage, hosted by OpenWetWare
I'm a senior physician (cunsultant) at the Department of Anaesthesiology and Intensive Care, University Hospital Tübingen, Eberhard Karls University Tübingen, Germany and member of the Antkowiak Lab
Berthold Drexler
Section for Experimental Anaesthesiology
Department of Anaesthesiology and Intensive Care, University Hospital Tuebingen
Waldhoernlestr. 22, 72072 Tuebingen, Germany
Email me through OpenWetWare
email: berthold DOT drexler AT uni MINUS tuebingen DOT de
skype: drexlerb
Education
- ATLS®-Provider ATLS
- Post Doctoral Fellowship: Experimental Anaesthesiology, Head: Prof. Dr. Bernd Antkowiak
- European Diploma in Intensive Care 11/2010
- Board Certification Intensive Care Medicine 11/2008
- European Diploma in Anaesthesiology 10/2007
- Board Certification Anaesthesiology 05/2007
- Internship/Residency: University Hospital Tübingen, Germany, Department of Anaesthesiology and Intensive Care, Head: Prof. Dr. Klaus Unertl
- Doctoral Thesis (MD), Albert-Ludwigs-University Freiburg, Cardiology, Supervisor: Prof. Dr. Christian Holubarsch
- Final Year: Internal Medicine Spital Uster, CH; Heart Surgery Groote Schuur Hospital, SA; Anaesthesiology University Hospital Freiburg
- Albert-Ludwigs-University, Medical School, Freiburg, Germany
Research interests
Mechanisms of Anaesthesia - GABAA Receptor Subtypes - Electrophysiology - Cortex - Organotypic Slice Cultures
Memberships
- Associate Faculty Member of the Faculty of 1000
- European Society of Anaesthesiology
- European Society of Intensive Care Medicine
- German Society for Anesthesiology and Intensive Care Medicine (DGAI)
- Selected mentee of the Mentoring Program for Junior Investigators (DGAI)
- Working Committee Neuroanaesthesia (DGAI)
Selected Publications
- Drexler B, Kreuzer M, Jordan D, Antkowiak B, Schneider G. Sevoflurane-induced loss of consciousness is paralleled by a prominent modification of neural activity during cortical down-states. Neurosci Letters 548:149-54; 2013 abstract
- Drexler B, Zinser S, Huang S, Poe MM, Rudolph U, Cook JM, Antkowiak B. Enhancing the function of alpha5-subunit-containing GABA(A) receptors promotes action potential firing of neocortical neurons during up-states. Eur J Pharmacol. 703(1-3): 18-24; 2013 abstract
- Drexler B, Antkowiak B, Engin E, Rudolph U: Identification and characterization of anesthetic targets by mouse molecular genetics approaches, Canadian Journal of Anesthesia 58: 178-190; 2011 PMC
- Drexler B, Hentschke H, Antkowiak B, Grasshoff C: Organotypic Cultures as Tools for Testing Neuroactive Drugs - Link Between In-Vitro and In-Vivo Experiments, Current Medicinal Chemistry 17(36): 4538-4550; 2010 abstract
- Drexler B, Zinser S, Hentschke H, Antkowiak B: Diazepam decreases action potential firing of neocortical neurons via two distinct mechanisms Anesthesia & Analgesia 111(6):1394-1399; 2010
- Drexler B, Jurd R, Rudolph U, Antkowiak B: Distinct actions of etomidate and propofol at β3-containing γ-aminobutyric acid type A receptors, Neuropharmacology 57 (4): 446-55, 2009 abstract and F1000
- Drexler B, Jurd R, Rudolph U, Antkowiak B: Dual Actions of Enflurane on Postsynaptic Currents Abolished by the γ-Aminobutyric Acid Type A Receptor β3(N265M) Point Mutation Anesthesiology 105: 297-304; 2006
- Drexler B, Roether CL, Jurd R, Rudolph U, Antkowiak B: Opposing Actions of Etomidate on Cortical Theta Oscillations Are Mediated by Different γ-Aminobutyric Acid Type A receptor subtypes Anesthesiology 102: 346-52; 2005
- Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt K, Ledermann B, Antkowiak B, Rudolph U: General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor β3 subunit FASEB J 17: 250-252; 2003
