View source for User:Blent/Seminar 07 fall

==Title==
* Toward Personalized Medicine in BMI-based Methodology: A case study of [http://en.wikipedia.org/wiki/Carbamazepine Carbamazepine] and challenges in the future

==Outlines (Sep 30, 2007)==
=== What is personalized medicine ===
* personalized biomedical data collection and analysis
** easy-to-use personalized diagnosis kit
* personalized biomedical date-driven medicine usage
** which medicine should one take? (decision of medicine)
** how much medicine should one take? (dosage of medicine)
* references
** [http://www.personalizedmedicinecoalition.org/ personalized medicine coalition]
** [http://www.genomenewsnetwork.org/articles/2004/10/28/matchingpatients.php Personalized Medicine in Cancer: Matching Patients and Drugs (Genome News Network, Oct 28th, 2004)]
*** [http://en.wikipedia.org/wiki/Gefitinib Gefitinib, a cancer drug]
** [http://www.boston.com/news/globe/editorial_opinion/oped/articles/2005/07/17/personalized_medicine/ Personalized medicine: A new approach to staying well (Boston Globe News, July 17th, 2005)]
** [http://www.fda.gov/fdac/features/2005/605_genomics.html Genomics and Personalized Medicine (FDA Consumer magazine, Nov-Dec 2005 issue)]
*** [http://www.fda.gov/cder/genomics/default.htm Genomics at FDA]
=== case study: CBZ-SJS === 
* [http://www.nature.com/nature/journal/v428/n6982/full/428486a.html Medical genetics: a marker for Stevens-Johnson syndrome, 2004 April Nature]
** HLA-B 1520 is an universal marker for Han Chinese in Taiwan
** [http://brc.se.fju.edu.tw/protein/analysis/ms.htm MS蛋白質序列分析]
** [MALDI-TOF mass spectrometry-based SNP genotyping, 2002 Pharmacogenomics]
** [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=11295828 High-throughput multiplex SNP genotyping with MALDI-TOF mass spectrometry: practice, problems and promise, 2001 Hum Mutat.]
* [http://www.nature.com/tpj/journal/v6/n4/full/6500356a.html A marker for Stevens-Johnson syndrome ...: ethnicity matters, 2006 The Pharmacogenomics Journal]
** HLA-B 1502 may '''NOT''' be an universal marker for CBZ-SJS
* [http://www.nature.com/nrd/journal/v4/n1/full/nrd1605.html Genetic aspects of immune-mediated adverse drug effects, 2005 Nature]
* [http://www.nature.com/jid/journal/v114/n1/full/5600617a.html Nitric Oxide Synthase in Toxic Epidermal Necrolysis and Stevens–Johnson Syndrome, 2000 Journal of Investigative Dermatology]
* [http://sa.ylib.com/news/newsshow.asp?FDocNo=438&CL=28 嚴重藥物過敏，可以預防 (科學人 2004 May)]
* [http://explore.pts.org.tw/p2.htm 公視 探索未知世界 第二集: 解毒生命密碼-基因與藥物過敏]
* [http://tw.myblog.yahoo.com/a_jun35/article?mid=1163&prev=1224&next=1161&l=f&fid=22 基因型鑑定 預防藥物過敏邁向個人化醫療 (中廣新聞網 3/8, 2007)]
* [http://drug.doh.gov.tw/bulletin_cnt.php?PHPSESSID=bg6ksuvuq317fmk4runq4232b6&Pact=bulletin&id=160 我國個人化醫療跨出一大步，讓藥害救濟由事後救濟邁向事前預防 (行政院衛生署藥物資訊網 9/17, 2007)]
* [http://www.libertytimes.com.tw/2007/new/sep/18/today-life7.htm 預防抗癲癇藥害 明年起先測基因 - 首見研究成果當警語 (自由時報生活新聞 9/18, 2007)]
* [http://www.epochtimes.com/b5/7/9/18/n1837459.htm 台灣獨步全球 預防抗癲癇藥害 - 明年起先測基因 首見研究成果當警語 (大紀元電子報 9/18, 2007)]
* [http://en.wikipedia.org/wiki/Carbamazepine Carbamazepine] is an long half-live drug

=== case study: Warfarin (抗凝血劑) and dosage estimation ===
* [http://www.aafp.org/afp/990201ap/635.html Warfarin Therapy: Evolving Strategies in Anticoagulation, Feb 1999, American Family Physician]
* [http://genome.wellcome.ac.uk/doc_WTD020935.html  Genetic variation (VKORC1) alters response to warfarin, 2/6/05. By NIH/National Institute of General Medical Sciences]
* [http://www.clinchem.org/cgi/content/full/53/9/1721 Genetic Factors for Warfarin Dose Prediction, 2007 Clinical Chemistry]

=== case study: Diabetes and Diagnosis ===
=== BioBank and Biomarkers discovery ===
=== case study: The First race-specific drug '''[http://www.bidil.com/ BiDil]'''===
* [http://www.liverx.org/2007/09/05/藥瓶裡的種族問題/ 活力藥師網番外篇-藥瓶裡的種族問題]
* [http://www.sciam.com/article.cfm?chanID=sa006&colID=1&articleID=B0FEC94D-E7F2-99DF-3CD8F25918B63A39 Race in a Bottle, Jonathan Kahn. (Sci Am 2007 Aug)]
* 藥瓶裡的種族問題 科學人 2007 Sep
* author: [http://www.hamline.edu/law/facadmin/jonathon_kahn.html Jonathan Kahn]
* [http://findarticles.com/p/articles/mi_m1365/is_4_36/ai_n15890897 Are race-specific drugs unethical? With BiDil on the market, experts weigh the moral implications, Nov 2005]
* [http://en.wikipedia.org/wiki/Isosorbide_dinitrate/hydralazine BiDil: Isosorbide dinitrate and hydralazine]
** [http://www.pharmacychecker.com/Pricing.asp?DrugName=Hydralazine&DrugId=18834&DrugStrengthId=30707 Hydralazine price]
** [http://www.pharmacychecker.com/Pricing.asp?DrugName=Isosorbide+Dinitrate&DrugId=18878&DrugStrengthId=30779 Isosorbide Dinitrate price]
** [http://www.pharmacychecker.com/Pricing.asp?DrugName=Bidil&DrugId=62798&DrugStrengthId=115893 BiDil price]
=== ELSI, Biobank and FDA guide lines ===
=== Movies ===
* [http://movie.starblvd.net/cgi-bin/movie/euccns?/film/1997/Gattaca/Gattaca.html Gattaca: 千鈞一髮 1997]

==Outlines (Sep 20, 2007) ==
* BMI = BI + MI
** what BMI can do
*** Neuroinformatics (NI)
*** Cancer research (CR)
* Personalized Medicine (PM)
** Motivation and case study
*** [http://en.wikipedia.org/wiki/Stevens-Johnson_syndrome Stevens-Johnson syndrome] and HLA-B 1502
** Methodology
*** MI
*** BI
** Products
** Problems remained
==Background==
* intersection between Bioinformatics and Medical Informatics
** [http://www.jamia.org/cgi/search?sendit=Search&pubdate_year=&volume=&firstpage=&DOI=&author1=&author2=&title=&andorexacttitle=and&titleabstract=bioinformatics&andorexacttitleabs=and&fulltext=&andorexactfulltext=and&resourcetype=1%2C10&fmonth=Jan&fyear=1994&tmonth=Sep&tyear=2007&fdatedef=1+January+1994&tdatedef=1+September+2007&hits=10&sortspec=relevance total search results]
** [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=264428&rendertype=abstract Bioinformatics and Medical Informatics: Collaborations on the Road to Genomic Medicine? 2003 JAMIA]
** [http://www.jamia.org/cgi/content/abstract/7/5/439 The Interactions Between Clinical Informatics and Bioinformatics, 2000 JAMIA]
** [http://www.jamia.org/cgi/content/abstract/7/5/431 Opportunities at the Intersection of Bioinformatics and Health Informatics, 2000 JAMIA]
** [http://www.jamia.org/cgi/content/abstract/11/3/167 Training the Next Generation of Informaticians: The Impact of "BISTI" and Bioinformatics—A Report from the American College of Medical Informatics, 2004 JAMIA]
** [http://www.jamia.org/cgi/content/abstract/9/5/509 Military Research Needs in Biomedical Informatics, 2000 JAMIA]
** [http://www.symbiomatics.org/page.php?page=home Synergies in Medical Informatics and Bioinformatics]
==Materials==
* [http://www.sciam.com/ Scientific American (English)]
* [http://sa.ylib.com/ Scientific American (Taiwan)]
* [http://www.bio-itworld.com/ BioIT]
* [http://www.genengnews.com/ Genetic Engineering & biotechnology News]
* [http://www.bioweb.com.tw/ 華文生技網]
* [http://140.119.115.32/sa/defaultx.asp 科學人知識庫]
==Notes==
* [[User:Blent/Scientific_American|Scientific American]]
* [[User:Blent/Biobank|Biobank]]