User:Blent/Seminar 07 fall

Title

• Toward Personalized Medicine in BMI-based Methodology: A case study of Carbamazepine and challenges in the future

Outlines (Sep 26, 2007)

• case study #1: The First race-specific drug Bibil
  • 活力藥師網番外篇
  • Race in a Bottle, Jonathan Kahn. (Sci Am 2007 Aug)
  • 科學人 2007 Sep
• case study #2: CBZ-SJS
  • 公視 探索未知世界 第二集: 解毒生命密碼-基因與藥物過敏
  • 嚴重藥物過敏，可以預防 (科學人 2004 May)
• Problem definition
• Solution constructed by BI + MI
  • Material and Method
    • Biomarkers discovery
• ELSI and FDA guide line

Background

• intersection between Bioinformatics and Medical Informatics
  • total search results
  • Bioinformatics and Medical Informatics: Collaborations on the Road to Genomic Medicine? 2003 JAMIA
  • The Interactions Between Clinical Informatics and Bioinformatics, 2000 JAMIA
  • Opportunities at the Intersection of Bioinformatics and Health Informatics, 2000 JAMIA
  • Training the Next Generation of Informaticians: The Impact of "BISTI" and Bioinformatics—A Report from the American College of Medical Informatics, 2004 JAMIA
  • Military Research Needs in Biomedical Informatics, 2000 JAMIA
  • Synergies in Medical Informatics and Bioinformatics

Materials

• Scientific American (English)
• Scientific American (Taiwan)
• BioIT
• Genetic Engineering & biotechnology News
• 華文生技網
• 科學人知識庫

Discussions

• Scientific American
• Biobank

Report Outlines

• BMI = BI + MI
  • what BMI can do
    • Neuroinformatics (NI)
    • Cancer research (CR)
• Personalized Medicine (PM)
  • Motivation and case study
    • Stevens-Johnson syndrome and HLA-B 1502
  • Methodology
    • MI
    • BI
  • Products
  • Problems remained