User:Blent/Seminar 07 fall

Title

• Toward Personalized Medicine in BMI-based Methodology: A case study of Carbamazepine and challenges in the future

Outlines (Sep 27, 2007)

• What is personalized medicine
  • personalized biomedical data collection and analysis
    • easy-to-use personalized diagnosis kit
  • personalized biomedical date-driven medicine usage
    • which medicine should one take? (decision of medicine)
    • how much medicine should one take? (dosage of medicine)
  • references
    • personalized medicine coalition
    • Personalized Medicine in Cancer: Matching Patients and Drugs (Genome News Network, Oct 28th, 2004)
      • Gefitinib, a cancer drug
    • Personalized medicine: A new approach to staying well (Boston Globe News, July 17th, 2005)
    • Genomics and Personalized Medicine (FDA Consumer magazine, Nov-Dec 2005 issue)
      • Genomics at FDA
• case study: CBZ-SJS
  • Medical genetics: a marker for Stevens-Johnson syndrome, Nature 2004 April
    • HLA-B 1520 is an universal marker for Han Chinese in Taiwan
  • A marker for Stevens-Johnson syndrome ...: ethnicity matters, The Pharmacogenomics Journal 2006
    • HLA-B 1502 may NOT be an universal marker for CBZ-SJS
  • 嚴重藥物過敏，可以預防 (科學人 2004 May)
  • 公視 探索未知世界 第二集: 解毒生命密碼-基因與藥物過敏
  • 基因型鑑定 預防藥物過敏邁向個人化醫療 (中廣新聞網 3/8, 2007)
  • 我國個人化醫療跨出一大步，讓藥害救濟由事後救濟邁向事前預防 (行政院衛生署藥物資訊網 9/17, 2007)
  • 預防抗癲癇藥害 明年起先測基因 - 首見研究成果當警語 (自由時報生活新聞 9/18, 2007)
  • 台灣獨步全球 預防抗癲癇藥害 - 明年起先測基因 首見研究成果當警語 (大紀元電子報 9/18, 2007)
  • Carbamazepine is an long half-live drug
• case study: Warfarin (抗凝血劑) and dosage estimation
  • Warfarin Therapy: Evolving Strategies in Anticoagulation, 1999 American Family Physician
  • Genetic variation (VKORC1) alters response to warfarin, 2/6/05. By NIH/National Institute of General Medical Sciences
• case study: Diabetes and Diagnosis
• BioBank and Biomarkers discovery
• case study: The First race-specific drug BiDil
  • 活力藥師網番外篇-藥瓶裡的種族問題
  • Race in a Bottle, Jonathan Kahn. (Sci Am 2007 Aug)
  • 藥瓶裡的種族問題 科學人 2007 Sep
  • author: Jonathan Kahn
  • Are race-specific drugs unethical? With BiDil on the market, experts weigh the moral implications, Nov 2005
  • price of BiDil
• ELSI, Biobank and FDA guide lines
• Movies
  • Gattaca: 千鈞一髮 1997

Outlines (Sep 20, 2007)

• BMI = BI + MI
  • what BMI can do
    • Neuroinformatics (NI)
    • Cancer research (CR)
• Personalized Medicine (PM)
  • Motivation and case study
    • Stevens-Johnson syndrome and HLA-B 1502
  • Methodology
    • MI
    • BI
  • Products
  • Problems remained

Background

• intersection between Bioinformatics and Medical Informatics
  • total search results
  • Bioinformatics and Medical Informatics: Collaborations on the Road to Genomic Medicine? 2003 JAMIA
  • The Interactions Between Clinical Informatics and Bioinformatics, 2000 JAMIA
  • Opportunities at the Intersection of Bioinformatics and Health Informatics, 2000 JAMIA
  • Training the Next Generation of Informaticians: The Impact of "BISTI" and Bioinformatics—A Report from the American College of Medical Informatics, 2004 JAMIA
  • Military Research Needs in Biomedical Informatics, 2000 JAMIA
  • Synergies in Medical Informatics and Bioinformatics

Materials

• Scientific American (English)
• Scientific American (Taiwan)
• BioIT
• Genetic Engineering & biotechnology News
• 華文生技網
• 科學人知識庫

Notes

• Scientific American
• Biobank