User:Bosworth

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will bosworth
bosworth AT mit.edu
mit class of 2008
pursing a bs in mechanical engineering with a minor in biology
currently a member of the UCBerkeley iGEM team 2006,
designing cellular logic gates in cells; creating and testing conjugation-based communication models 
in e.coli . Continuing this project in the endy lab @ mit in fall2006. 
previously a member of the MIT iGEM team 2005, where 
I did alot of struggling and learning. We tried to modify a chemical pathway to create a platform to 
sense different environmental factors. Our method involved significantly modifying surface protein's
structures (synthesizing altered sequences) and then expecting those proteins to still work. We did
not get very far. 


concrete interests: 
# bio-electro-mechanical system design and MEMS - living cell interaction
# electro-mechanical motion control & creating the mechanisms and terminology for analogous control in biological systems. 
# quantitative models matching actual results. 
# I must be interested in something that doesn't sound "far out and far away," too.

abstract interests: 
# innovation 
# righteous engineering 
# good design (in any form)
# self assembly
# abstraction
# exploring and managing complexity
# simplicity
# big words



Will Bosworth Fall 2006 iGEM UROP proposal.

This term I will continue work on the 2006 UC Berkeley iGEM project. iGEM is the international Genetically Engineered Machine Competition, a student competition where teams design and assemble engineered machines using advanced genetic components and technologies .

In this project we are developing the necessary low level components and higher level schemes to create logical computation circuits implemented in networks of cells.

To create these networks, we have developed a model for a NAND operator that uses three unique cell types to perform a logical operation. This NAND operator is designed to be modular. The number of unique independent NAND gates will scale with the creation of lower-level communication modules that do not cross-talk.

This fall, I will attempt to build a single NAND gate operator in order to demonstrate this system at the iGEM Jamboree held in early November 2006. I will be doing wet lab work in Professor Drew Endy's lab in Building 68. Professor Endy is directly involved in the iGEM competition, and thus his lab is an ideal location for this research project.

More details of the 2006 UCB iGEM project can be found at: http://parts.mit.edu/wiki/index.php/University_of_California_Berkeley_2006

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