User:Carsten C. Mahrenholz: Difference between revisions
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==Education== | ==Education== | ||
<!--Include info about your educational background--> | <!--Include info about your educational background--> | ||
* | * 2006-'''2010''' PhD (Boichemistry) | ||
Institute of Medical Immunology, Charité Medical School, Berlin | Institute of Medical Immunology, Charité Medical School, Berlin and | ||
Freie University, Berlin | |||
* 2001-2005 | * 2001-'''2005''' Dipl. Biol. (Molecular Biology, Biophysics, Immunology) | ||
Humboldt University, Berlin and Gutenberg University, Mainz | Humboldt University, Berlin and | ||
Gutenberg University, Mainz | |||
* 2006-2008 | * 2006-'''2008''' MBA (General Management - Dual Award) | ||
Berlin School of Economics and Ashcroft International Business School, Cambridge | Berlin School of Economics, Berlin and | ||
Ashcroft International Business School, Cambridge, UK | |||
==Research interests== | ==Research interests== | ||
<!-- Feel free to add brief descriptions to your research interests as well --> | <!-- Feel free to add brief descriptions to your research interests as well --> | ||
# Coiled-Coil interaction, stoichometry and peptide design | # Coiled-Coil interaction, stoichometry and peptide design (We use ''biochemical'' high-throughput(SPOT- and Peptide-Synthesis) methods, ''biophysics'' (ITC, AUZ, Biacore) and ''informatics'' (SVM) to define the rules of association on the amino-acid level.) | ||
# association landscapes for coiled-coil protein interaction | |||
# association landscapes for protein interaction | |||
# evolution theory | # evolution theory | ||
# bionic economics | |||
==Publications== | ==Publications== | ||
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications. You can add or remove lines as needed --> | <!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications. You can add or remove lines as needed --> | ||
<biblio> | <biblio> | ||
# | |||
# | #Ay, B., Streitz, M., Boisguerin, P., '''Mahrenholz, C.C.''', Schuck, S.D., Kern, F., Volkmer, R., Sorting and pooling strategy: a novel tool to map a virus proteome for CD8 T-cell epitopes. ''Biopolymers'' '''88''' (1): 64-75 (2007) | ||
// | #Portwich, M., Keller, S., Strauss, H.M., '''Mahrenholz, C.C.''', Kretzschmar, I., Kramer, A., Volkmer, R., A Network of Coiled Coil Associations Derived from Synthetic GCN4 Leucine Zipper Arrays. ''Angew Chem Int Ed'' '''46''' (10): 1654-1657 (2007) | ||
#''and'' Portwich, M., Keller, S., Strauss, H.M., '''Mahrenholz, C.C.''', Kretzschmar, I., Kramer, A., Volkmer, R., Ein mithilfe synthetischer GCN4-Leucinzipperarrays aufgedecktes Coiled-Coil-Assoziationsnetzwerk. ''Angew Chem'' '''119''' (10): 1682-1686 (2007) | |||
#'''Mahrenholz, C.C.'''*, Fidan, Z.*, Portwich, M., Volkmer, R., Analysis of coiled coil associations by SPOT technology. ''Chem Today'' '''26''' (2): 22-25 (2008) | |||
#'''Mahrenholz, C.C.''', Tapia, V., Stigler, R., Volkmer, R., A study to assess the crossreactivity of cellulose membrane-bound peptides with detection systems: an analysis at the amino acid level. ''J Pept Sci'' '''16''': 297–302 (2010) | |||
#'''Mahrenholz, C.C.'''*, Abfalter, I.G.*, Bodenhofer, U., Volkmer, R., Hochreiter, S., Complex networks govern coiled coil oligomerization: Predicting and profiling by means of a machine learning approach. ''Mol Cell Proteomics'' '''10'''(5): M110.004994 (2011) | |||
#Czarna, A., Riffkin, H., '''Mahrenholz, C.C.''', Arens, J., Strauss, H.,Wolf, E., Quantitative analyses of mouse Cryptochrome - Bmal1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock. '''J Biol Chem''' Apr 25. [Epub ahead of print] (2011) | |||
#Patent1 '''Mahrenholz CC''' and Portwich M. ''Peptides interacting with alpha-helical coiled-coil streuctures and/or coiled-coil sequences, substances derived therefrom, and use thereof'' (WO/2007/068240) | |||
</biblio> | </biblio> | ||
==Communications and Talks== | |||
# '''Mahrenholz CC''', Schuck S, Kretzschmar I, Ay B, Volkmer R. ''An optimized SPOT synthesis protocol: High-throughput synthesis of peptides with authentic and free C-termini.'' Chem Bio Net (2005) | |||
# Volkmer R, Portwich M, Strauss HM, '''Mahrenholz CC''', Kretzschmar I, Keller, S. ''Analysis of coiled-coil associations by SPOT technology and biophysics''. 8th German Peptide Symposium (2007) | |||
# '''Mahrenholz CC''', ''Promiscuous coiled-coils and their pharmacological potential.'' 6th Bionnale (2008) | |||
# Abfalter IG*, '''Mahrenholz CC*''', Bodenhofer U, Hochreiter S. ''Analyzing Coiled Coil Proteins With Support Vector Machines to Design New Anti-Viral Drugs''. Intelligent Systems for Molecular Biology (2008) | |||
# '''Mahrenholz CC''', Tapia V, Stigler R, Volkmer R. ''Peptides crossreacting with detection systems – Analysis at the amino acid level''. 9th Peptide Symposium (2009) | |||
# '''Mahrenholz CC*''', Abfalter IG*, Bodenhofer U, Volkmer R, Hochreiter S. ''Defining distinctive rules for stoichiometry and recognition of coiled coil proteins using bioinformatical methods''. 9th Peptide Symposium (2009) | |||
#Abfalter, I.G.*, '''Mahrenholz, C.C.'''*, Bodenhofer, U., Hochreiter, S., ''New insights into coiled coil formation by means of support vector machines.'' European Conference on Computational Biology and ISMB (2009) | |||
#'''Mahrenholz, C.C.''', Portwich, M., Abfalter, I.G., Volkmer, R., ''Coiled coil formation: a multi-method approach to solve a glass bead game.'' Protein Modules and Networks in Health and Desease (2009) | |||
#Volkmer, R., '''Mahrenholz, C.C.''', Otte, L., Landgraf, C., ''Investigation of coiled coil domain based associations with synthetic peptide arrays: advantages and limitations.'' Protein Modules and Networks in Health and Desease (2009) | |||
#'''Mahrenholz, C.C.''', Tapia, V., Stigler, R., Volkmer, R., ''Detection systems cross reacting with peptides – Analysis at the amino acid level.'' Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2010.4448.1> (2010) | |||
#'''Mahrenholz, C.C.''', Tapia, V., Stigler, R.D., Volkmer, R., ''A study to assess the crossreactivity of cellulose membrane bound peptides with detection systems: An analysis at the amino acid level.'' 31th European Peptide Symposium (2010) | |||
#'''Mahrenholz, C.C.''', Abfalter, I.G., Bodenhofer, U., Volkmer, R., Hochreiter, S., ''Complex networks govern coiled coil oligomerization: A multi-method approach.'' 31st European Peptide Symposium (2010) | |||
#Bodenhofer, U., Kothmeier, A., Abfalter, I.G., '''Mahrenholz, C.C.''', Hochreiter, S., ''Decoding Sequence Classification Models for Acquiring New Biological Insights.'' 18th International Conference on Intelligent Systems for Molecular Biology. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2010.4708.1> (2010) | |||
#'''Mahrenholz, C.C.'''*, Abfalter, I.G.*, Bodenhofer, U., Volkmer, R., Hochreiter, S., ''PrOCoil - Advances in predicting two- and three-stranded coiled coils.'' 18th International Conference on Intelligent Systems for Molecular Biology. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2010.4677.1> (2010) | |||
==Useful links== | ==Useful links== | ||
*[[OpenWetWare:Welcome|Introductory tutorial]] | *[[OpenWetWare:Welcome|Introductory tutorial]] | ||
*[[Help|OpenWetWare help pages]] | *[[Help|OpenWetWare help pages]] |
Latest revision as of 13:57, 20 June 2011
I am a new member of OpenWetWare!
Contact Info
- Carsten C. Mahrenholz
- Molecular Libraries and Recognition Group
- Charité Medical School
- Berlin, Germany
- Email me through OpenWetWare
I work in the Institute of Medical Immunology at Charité Medical School. I've joined because Hopefully I can find some people to share information about my phd-topics (coiled-coils and SPOT-synthesis) and add some related methodical and input value.
Education
- 2006-2010 PhD (Boichemistry)
Institute of Medical Immunology, Charité Medical School, Berlin and Freie University, Berlin
- 2001-2005 Dipl. Biol. (Molecular Biology, Biophysics, Immunology)
Humboldt University, Berlin and Gutenberg University, Mainz
- 2006-2008 MBA (General Management - Dual Award)
Berlin School of Economics, Berlin and Ashcroft International Business School, Cambridge, UK
Research interests
- Coiled-Coil interaction, stoichometry and peptide design (We use biochemical high-throughput(SPOT- and Peptide-Synthesis) methods, biophysics (ITC, AUZ, Biacore) and informatics (SVM) to define the rules of association on the amino-acid level.)
- association landscapes for coiled-coil protein interaction
- evolution theory
- bionic economics
Publications
-
, B., Streitz, M., Boisguerin, P., Mahrenholz, C.C., Schuck, S.D., Kern, F., Volkmer, R., Sorting and pooling strategy: a novel tool to map a virus proteome for CD8 T-cell epitopes. Biopolymers 88 (1): 64-75 (2007)
-
, M., Keller, S., Strauss, H.M., Mahrenholz, C.C., Kretzschmar, I., Kramer, A., Volkmer, R., A Network of Coiled Coil Associations Derived from Synthetic GCN4 Leucine Zipper Arrays. Angew Chem Int Ed 46 (10): 1654-1657 (2007)
-
Portwich, M., Keller, S., Strauss, H.M., Mahrenholz, C.C., Kretzschmar, I., Kramer, A., Volkmer, R., Ein mithilfe synthetischer GCN4-Leucinzipperarrays aufgedecktes Coiled-Coil-Assoziationsnetzwerk. Angew Chem 119 (10): 1682-1686 (2007)
-
, C.C.*, Abfalter, I.G.*, Bodenhofer, U., Volkmer, R., Hochreiter, S., Complex networks govern coiled coil oligomerization: Predicting and profiling by means of a machine learning approach. Mol Cell Proteomics 10(5): M110.004994 (2011)
-
, C.C.*, Fidan, Z.*, Portwich, M., Volkmer, R., Analysis of coiled coil associations by SPOT technology. Chem Today 26 (2): 22-25 (2008)
-
, C.C., Tapia, V., Stigler, R., Volkmer, R., A study to assess the crossreactivity of cellulose membrane-bound peptides with detection systems: an analysis at the amino acid level. J Pept Sci 16: 297–302 (2010)
-
, A., Riffkin, H., Mahrenholz, C.C., Arens, J., Strauss, H.,Wolf, E., Quantitative analyses of mouse Cryptochrome - Bmal1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock. J Biol Chem Apr 25. [Epub ahead of print] (2011)
-
Mahrenholz CC and Portwich M. Peptides interacting with alpha-helical coiled-coil streuctures and/or coiled-coil sequences, substances derived therefrom, and use thereof (WO/2007/068240)
Communications and Talks
- Mahrenholz CC, Schuck S, Kretzschmar I, Ay B, Volkmer R. An optimized SPOT synthesis protocol: High-throughput synthesis of peptides with authentic and free C-termini. Chem Bio Net (2005)
- Volkmer R, Portwich M, Strauss HM, Mahrenholz CC, Kretzschmar I, Keller, S. Analysis of coiled-coil associations by SPOT technology and biophysics. 8th German Peptide Symposium (2007)
- Mahrenholz CC, Promiscuous coiled-coils and their pharmacological potential. 6th Bionnale (2008)
- Abfalter IG*, Mahrenholz CC*, Bodenhofer U, Hochreiter S. Analyzing Coiled Coil Proteins With Support Vector Machines to Design New Anti-Viral Drugs. Intelligent Systems for Molecular Biology (2008)
- Mahrenholz CC, Tapia V, Stigler R, Volkmer R. Peptides crossreacting with detection systems – Analysis at the amino acid level. 9th Peptide Symposium (2009)
- Mahrenholz CC*, Abfalter IG*, Bodenhofer U, Volkmer R, Hochreiter S. Defining distinctive rules for stoichiometry and recognition of coiled coil proteins using bioinformatical methods. 9th Peptide Symposium (2009)
- Abfalter, I.G.*, Mahrenholz, C.C.*, Bodenhofer, U., Hochreiter, S., New insights into coiled coil formation by means of support vector machines. European Conference on Computational Biology and ISMB (2009)
- Mahrenholz, C.C., Portwich, M., Abfalter, I.G., Volkmer, R., Coiled coil formation: a multi-method approach to solve a glass bead game. Protein Modules and Networks in Health and Desease (2009)
- Volkmer, R., Mahrenholz, C.C., Otte, L., Landgraf, C., Investigation of coiled coil domain based associations with synthetic peptide arrays: advantages and limitations. Protein Modules and Networks in Health and Desease (2009)
- Mahrenholz, C.C., Tapia, V., Stigler, R., Volkmer, R., Detection systems cross reacting with peptides – Analysis at the amino acid level. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2010.4448.1> (2010)
- Mahrenholz, C.C., Tapia, V., Stigler, R.D., Volkmer, R., A study to assess the crossreactivity of cellulose membrane bound peptides with detection systems: An analysis at the amino acid level. 31th European Peptide Symposium (2010)
- Mahrenholz, C.C., Abfalter, I.G., Bodenhofer, U., Volkmer, R., Hochreiter, S., Complex networks govern coiled coil oligomerization: A multi-method approach. 31st European Peptide Symposium (2010)
- Bodenhofer, U., Kothmeier, A., Abfalter, I.G., Mahrenholz, C.C., Hochreiter, S., Decoding Sequence Classification Models for Acquiring New Biological Insights. 18th International Conference on Intelligent Systems for Molecular Biology. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2010.4708.1> (2010)
- Mahrenholz, C.C.*, Abfalter, I.G.*, Bodenhofer, U., Volkmer, R., Hochreiter, S., PrOCoil - Advances in predicting two- and three-stranded coiled coils. 18th International Conference on Intelligent Systems for Molecular Biology. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2010.4677.1> (2010)