User:Carsten C. Mahrenholz

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==Education==
==Education==
<!--Include info about your educational background-->
<!--Include info about your educational background-->
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* since 2005, PhD student (Boichemistry)  
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* 2006-'''2010'''  PhD (Boichemistry)  
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               Institute of Medical Immunology, Charité Medical School, Berlin
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               Institute of Medical Immunology, Charité Medical School, Berlin and
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              Freie University, Berlin
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* 2001-2005, Dipl. Biol. (Molecular Biology, Biophysics, Immunology)  
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* 2001-'''2005''' Dipl. Biol. (Molecular Biology, Biophysics, Immunology)  
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               Humboldt University, Berlin and Gutenberg University, Mainz
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               Humboldt University, Berlin and  
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              Gutenberg University, Mainz
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* 2006-2008, MBA (General Management - Dual Award)
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* 2006-'''2008''' MBA (General Management - Dual Award)
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               Berlin School of Economics and Ashcroft International Business School, Cambridge
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               Berlin School of Economics, Berlin and  
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              Ashcroft International Business School, Cambridge, UK
==Research interests==
==Research interests==
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# association landscapes for coiled-coil protein interaction
# association landscapes for coiled-coil protein interaction
# evolution theory
# evolution theory
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# bionic economics
==Publications==
==Publications==
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications.  You can add or remove lines as needed -->
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications.  You can add or remove lines as needed -->
<biblio>
<biblio>
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#Ay, B., Streitz, M., Boisguerin, P., '''Mahrenholz, C.C.''', Schuck, S.D., Kern, F., Volkmer, R., Sorting and pooling strategy: a novel tool to map a virus proteome for CD8 T-cell epitopes. ''Biopolymers'' '''88''' (1): 64-75 (2007)
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#Portwich, M., Keller, S., Strauss, H.M., '''Mahrenholz, C.C.''', Kretzschmar, I., Kramer, A., Volkmer, R., A Network of Coiled Coil Associations Derived from Synthetic GCN4 Leucine Zipper Arrays. ''Angew Chem Int Ed'' '''46''' (10): 1654-1657 (2007)
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#''and'' Portwich, M., Keller, S., Strauss, H.M., '''Mahrenholz, C.C.''', Kretzschmar, I., Kramer, A., Volkmer, R., Ein mithilfe synthetischer GCN4-Leucinzipperarrays aufgedecktes Coiled-Coil-Assoziationsnetzwerk. ''Angew Chem'' '''119''' (10): 1682-1686 (2007)
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#'''Mahrenholz, C.C.'''*, Fidan, Z.*, Portwich, M., Volkmer, R., Analysis of coiled coil associations by SPOT technology. ''Chem Today'' '''26''' (2): 22-25 (2008)
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#'''Mahrenholz, C.C.''', Tapia, V., Stigler, R., Volkmer, R., A study to assess the crossreactivity of cellulose membrane-bound peptides with detection systems: an analysis at the amino acid level. ''J Pept Sci'' '''16''': 297–302 (2010)
 +
#'''Mahrenholz, C.C.'''*, Abfalter, I.G.*, Bodenhofer, U., Volkmer, R., Hochreiter, S., Complex networks govern coiled coil oligomerization: Predicting and profiling by means of a machine learning approach. ''Mol Cell Proteomics'' '''10'''(5): M110.004994 (2011)
 +
#Czarna, A., Riffkin, H., '''Mahrenholz, C.C.''', Arens, J., Strauss, H.,Wolf, E., Quantitative analyses of mouse Cryptochrome - Bmal1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock. '''J Biol Chem''' Apr 25. [Epub ahead of print] (2011)
#Patent1 '''Mahrenholz CC''' and Portwich M. ''Peptides interacting with alpha-helical coiled-coil streuctures and/or coiled-coil sequences, substances derived therefrom, and use thereof'' (WO/2007/068240)
#Patent1 '''Mahrenholz CC''' and Portwich M. ''Peptides interacting with alpha-helical coiled-coil streuctures and/or coiled-coil sequences, substances derived therefrom, and use thereof'' (WO/2007/068240)
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#Paper1 pmid=17211913
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#Paper2 pmid=17117459
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#Paper3 Fidan Z*, '''Mahrenholz CC*''', Portwich M, Volkmer R. ''Analyses of coiled-coil associations by SPOT technology.'' Chem Today 2008; 26(2) 28-32.
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</biblio>
</biblio>
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# Volkmer R, Portwich M, Strauss HM, '''Mahrenholz CC''', Kretzschmar I, Keller, S. ''Analysis of coiled-coil associations by SPOT technology and biophysics''. 8th German Peptide Symposium (2007)
# Volkmer R, Portwich M, Strauss HM, '''Mahrenholz CC''', Kretzschmar I, Keller, S. ''Analysis of coiled-coil associations by SPOT technology and biophysics''. 8th German Peptide Symposium (2007)
# '''Mahrenholz CC''', ''Promiscuous coiled-coils and their pharmacological potential.'' 6th Bionnale (2008)
# '''Mahrenholz CC''', ''Promiscuous coiled-coils and their pharmacological potential.'' 6th Bionnale (2008)
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# Abfalter IG*, '''Mahrenholz CC*''', Bodenhofer U, Hochreiter S. ''Analyzing Coiled Coil Proteins With Support Vector Machines to Design New Anti-Viral Drugs''.
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# Abfalter IG*, '''Mahrenholz CC*''', Bodenhofer U, Hochreiter S. ''Analyzing Coiled Coil Proteins With Support Vector Machines to Design New Anti-Viral Drugs''. Intelligent Systems for Molecular Biology (2008)
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Intelligent Systems for Molecular Biology (2008)
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# '''Mahrenholz CC''', Tapia V, Stigler R, Volkmer R. ''Peptides crossreacting with detection systems – Analysis at the amino acid level''. 9th Peptide Symposium (2009)
 +
# '''Mahrenholz CC*''', Abfalter IG*, Bodenhofer U, Volkmer R, Hochreiter S. ''Defining distinctive rules for stoichiometry and recognition of coiled coil proteins using bioinformatical methods''. 9th Peptide Symposium (2009)
 +
#Abfalter, I.G.*, '''Mahrenholz, C.C.'''*, Bodenhofer, U., Hochreiter, S., ''New insights into coiled coil formation by means of support vector machines.'' European Conference on Computational Biology and ISMB (2009)
 +
#'''Mahrenholz, C.C.''', Portwich, M., Abfalter, I.G., Volkmer, R., ''Coiled coil formation: a multi-method approach to solve a glass bead game.'' Protein Modules and Networks in Health and Desease (2009)
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#Volkmer, R., '''Mahrenholz, C.C.''', Otte, L., Landgraf, C., ''Investigation of coiled coil domain based associations with synthetic peptide arrays: advantages and limitations.'' Protein Modules and Networks in Health and Desease (2009)
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#'''Mahrenholz, C.C.''', Tapia, V., Stigler, R., Volkmer, R., ''Detection systems cross reacting with peptides – Analysis at the amino acid level.'' Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2010.4448.1> (2010)
 +
#'''Mahrenholz, C.C.''', Tapia, V., Stigler, R.D., Volkmer, R., ''A study to assess the crossreactivity of cellulose membrane bound peptides with detection systems: An analysis at the amino acid level.'' 31th European Peptide Symposium (2010)
 +
#'''Mahrenholz, C.C.''', Abfalter, I.G., Bodenhofer, U., Volkmer, R., Hochreiter, S., ''Complex networks govern coiled coil oligomerization: A multi-method approach.'' 31st European Peptide Symposium (2010)
 +
#Bodenhofer, U., Kothmeier, A., Abfalter, I.G., '''Mahrenholz, C.C.''', Hochreiter, S., ''Decoding Sequence Classification Models for Acquiring New Biological Insights.'' 18th International Conference on Intelligent Systems for Molecular Biology. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2010.4708.1> (2010)
 +
#'''Mahrenholz, C.C.'''*, Abfalter, I.G.*, Bodenhofer, U., Volkmer, R., Hochreiter, S., ''PrOCoil - Advances in predicting two- and three-stranded coiled coils.'' 18th International Conference on Intelligent Systems for Molecular Biology. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2010.4677.1> (2010)
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Current revision

I am a new member of OpenWetWare!

Contents

Contact Info

Carsten C. Mahrenholz (an artistic interpretation)
Carsten C. Mahrenholz (an artistic interpretation)
  • Carsten C. Mahrenholz
  • Molecular Libraries and Recognition Group
  • Charité Medical School

I work in the Institute of Medical Immunology at Charité Medical School. I've joined because Hopefully I can find some people to share information about my phd-topics (coiled-coils and SPOT-synthesis) and add some related methodical and input value.

Education

  • 2006-2010 PhD (Boichemistry)
             Institute of Medical Immunology, Charité Medical School, Berlin and
             Freie University, Berlin
  • 2001-2005 Dipl. Biol. (Molecular Biology, Biophysics, Immunology)
             Humboldt University, Berlin and 
             Gutenberg University, Mainz
  • 2006-2008 MBA (General Management - Dual Award)
             Berlin School of Economics, Berlin and 
             Ashcroft International Business School, Cambridge, UK

Research interests

  1. Coiled-Coil interaction, stoichometry and peptide design (We use biochemical high-throughput(SPOT- and Peptide-Synthesis) methods, biophysics (ITC, AUZ, Biacore) and informatics (SVM) to define the rules of association on the amino-acid level.)
  2. association landscapes for coiled-coil protein interaction
  3. evolution theory
  4. bionic economics

Publications

  1. , B., Streitz, M., Boisguerin, P., Mahrenholz, C.C., Schuck, S.D., Kern, F., Volkmer, R., Sorting and pooling strategy: a novel tool to map a virus proteome for CD8 T-cell epitopes. Biopolymers 88 (1): 64-75 (2007) [Ay]
  2. , M., Keller, S., Strauss, H.M., Mahrenholz, C.C., Kretzschmar, I., Kramer, A., Volkmer, R., A Network of Coiled Coil Associations Derived from Synthetic GCN4 Leucine Zipper Arrays. Angew Chem Int Ed 46 (10): 1654-1657 (2007) [Portwich]
  3. Portwich, M., Keller, S., Strauss, H.M., Mahrenholz, C.C., Kretzschmar, I., Kramer, A., Volkmer, R., Ein mithilfe synthetischer GCN4-Leucinzipperarrays aufgedecktes Coiled-Coil-Assoziationsnetzwerk. Angew Chem 119 (10): 1682-1686 (2007) [and]
  4. , C.C.*, Abfalter, I.G.*, Bodenhofer, U., Volkmer, R., Hochreiter, S., Complex networks govern coiled coil oligomerization: Predicting and profiling by means of a machine learning approach. Mol Cell Proteomics 10(5): M110.004994 (2011) [Mahrenholz]
  5. , C.C.*, Fidan, Z.*, Portwich, M., Volkmer, R., Analysis of coiled coil associations by SPOT technology. Chem Today 26 (2): 22-25 (2008) [Mahrenholz]
  6. , C.C., Tapia, V., Stigler, R., Volkmer, R., A study to assess the crossreactivity of cellulose membrane-bound peptides with detection systems: an analysis at the amino acid level. J Pept Sci 16: 297–302 (2010) [Mahrenholz]
  7. , A., Riffkin, H., Mahrenholz, C.C., Arens, J., Strauss, H.,Wolf, E., Quantitative analyses of mouse Cryptochrome - Bmal1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock. J Biol Chem Apr 25. [Epub ahead of print] (2011) [Czarna]
  8. Mahrenholz CC and Portwich M. Peptides interacting with alpha-helical coiled-coil streuctures and/or coiled-coil sequences, substances derived therefrom, and use thereof (WO/2007/068240) [Patent1]

Communications and Talks

  1. Mahrenholz CC, Schuck S, Kretzschmar I, Ay B, Volkmer R. An optimized SPOT synthesis protocol: High-throughput synthesis of peptides with authentic and free C-termini. Chem Bio Net (2005)
  2. Volkmer R, Portwich M, Strauss HM, Mahrenholz CC, Kretzschmar I, Keller, S. Analysis of coiled-coil associations by SPOT technology and biophysics. 8th German Peptide Symposium (2007)
  3. Mahrenholz CC, Promiscuous coiled-coils and their pharmacological potential. 6th Bionnale (2008)
  4. Abfalter IG*, Mahrenholz CC*, Bodenhofer U, Hochreiter S. Analyzing Coiled Coil Proteins With Support Vector Machines to Design New Anti-Viral Drugs. Intelligent Systems for Molecular Biology (2008)
  5. Mahrenholz CC, Tapia V, Stigler R, Volkmer R. Peptides crossreacting with detection systems – Analysis at the amino acid level. 9th Peptide Symposium (2009)
  6. Mahrenholz CC*, Abfalter IG*, Bodenhofer U, Volkmer R, Hochreiter S. Defining distinctive rules for stoichiometry and recognition of coiled coil proteins using bioinformatical methods. 9th Peptide Symposium (2009)
  7. Abfalter, I.G.*, Mahrenholz, C.C.*, Bodenhofer, U., Hochreiter, S., New insights into coiled coil formation by means of support vector machines. European Conference on Computational Biology and ISMB (2009)
  8. Mahrenholz, C.C., Portwich, M., Abfalter, I.G., Volkmer, R., Coiled coil formation: a multi-method approach to solve a glass bead game. Protein Modules and Networks in Health and Desease (2009)
  9. Volkmer, R., Mahrenholz, C.C., Otte, L., Landgraf, C., Investigation of coiled coil domain based associations with synthetic peptide arrays: advantages and limitations. Protein Modules and Networks in Health and Desease (2009)
  10. Mahrenholz, C.C., Tapia, V., Stigler, R., Volkmer, R., Detection systems cross reacting with peptides – Analysis at the amino acid level. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2010.4448.1> (2010)
  11. Mahrenholz, C.C., Tapia, V., Stigler, R.D., Volkmer, R., A study to assess the crossreactivity of cellulose membrane bound peptides with detection systems: An analysis at the amino acid level. 31th European Peptide Symposium (2010)
  12. Mahrenholz, C.C., Abfalter, I.G., Bodenhofer, U., Volkmer, R., Hochreiter, S., Complex networks govern coiled coil oligomerization: A multi-method approach. 31st European Peptide Symposium (2010)
  13. Bodenhofer, U., Kothmeier, A., Abfalter, I.G., Mahrenholz, C.C., Hochreiter, S., Decoding Sequence Classification Models for Acquiring New Biological Insights. 18th International Conference on Intelligent Systems for Molecular Biology. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2010.4708.1> (2010)
  14. Mahrenholz, C.C.*, Abfalter, I.G.*, Bodenhofer, U., Volkmer, R., Hochreiter, S., PrOCoil - Advances in predicting two- and three-stranded coiled coils. 18th International Conference on Intelligent Systems for Molecular Biology. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2010.4677.1> (2010)

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