User:Cbeisel

Chase Beisel

email: cbeisel@caltech.edu

phone: 626-395-2680

mail: MC 210-41 Pasadena, CA 91125

I am currently a chemical engineering graduate student in Christina Smolke's group at Caltech.

During my undergraduate days of old, I attended Iowa State University and worked in the labs of Peter Reilly and Jacqueline Shanks. I was also an active member of the Iowa State Drumline.

Research Interests

Organisms have found truly exceptional ways to translate a set of basic biomolecules into robust, interacting networks of finely-tuned components. I am interested in studying the available design space of biomolecules in a cellular environment by engineering devices at the molecular scale to produce defined phenotypic responses. Currently, I am exploring the combination of substrates of RNA interference and RNA aptamers to generate molecules that can survey the cellular environment and regulate gene expression accordingly. In the future, I hope to incorporate these molecules into endogenous genetic networks and explore their effectiveness.

Publications

1. Beisel CL and Smolke CD. Design principles for riboswitch function. PLoS Comput Biol 2009 (accepted).

2. Bayer TS, Hoff KG, Beisel CL, Lee JJ, and Smolke CD. Synthetic control of a fitness tradeoff in yeast nitrogen metabolism. J Biol Eng. 2009 Jan 2;3:1. DOI:10.1186/1754-1611-3-1 |
3. Beisel CL, Bayer TS, Hoff KG, and Smolke CD. Model-guided design of ligand-regulated RNAi for programmable control of gene expression. Mol Syst Biol. 2008;4:224. DOI:10.1038/msb.2008.62 |

4. Beisel CL, Dowd MK, and Reilly PJ. Conformational analysis of gossypol and its derivatives by molecular mechanics. J Mol Struct THEOCHEM 2005; 730 51-58.

5. Judice TN, Nelson NC, Beisel CL, Delimont DC, Fritzsch B, and Beisel KW. Cochlear whole mount in situ hybridization: identification of longitudinal and radial gradients. Brain Res Brain Res Protoc. 2002 Feb;9(1):65-76. DOI:10.1016/s1385-299x(01)00138-6 |