User:Cbeisel: Difference between revisions

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=Chase Beisel=
=Chase Beisel=


email: cbeisel@caltech.edu
email: beiselcl@mail.nih.gov


phone: 626-395-2680
phone: 301-496-4722


mail: MC 210-41 Pasadena, CA 91125
I am a postdoctoral fellow in [http://cbmp.nichd.nih.gov/segr/index.html Gisela Storz's group] at the National Institute of Child Health and Human Development. My research currently focuses on studying the regulatory characteristics of bacterial small RNAs in stress responses. Prior to joining the Storz group, I was a graduate student in Christina Smolke's group at [http://www.caltech.edu Caltech].


 
During my undergraduate days at [http://www.iastate.edu Iowa State University], I worked in the groups of [http://www.cbe.iastate.edu/reilly.html Peter Reilly], [http://www.cbe.iastate.edu/jshanks.html Jacqueline Shanks], and [http://www.cbe.iastate.edu/glatz.html Charles Glatz]. I was also an active member of the [http://www.music.iastate.edu/org/drumline/index.html Iowa State Drumline].
I am currently a chemical engineering graduate student in Christina Smolke's group at [http://www.caltech.edu Caltech].
 
 
During my undergraduate days of old, I attended [http://www.iastate.edu Iowa State University] and worked in the labs of [http://www.cbe.iastate.edu/reilly.html Peter Reilly] and [http://www.cbe.iastate.edu/jshanks.html Jacqueline Shanks]. I was also an active member of the [http://www.music.iastate.edu/org/drumline/index.html Iowa State Drumline].


=Research Interests=
=Research Interests=
Organisms have found truly exceptional ways to translate a set of basic biomolecules into robust, interacting networks of finely-tuned components. I am interested in studying the available design space of biomolecules in a cellular environment by engineering devices at the molecular scale to produce defined phenotypic responses. Currently, I am exploring the combination of substrates of RNA interference and RNA aptamers to generate molecules that can survey the cellular environment and regulate gene expression accordingly. In the future, I hope to incorporate these molecules into endogenous genetic networks and explore their effectiveness.
I am interested in the regulatory capacity of RNA and how RNA can be exploited to program biological systems. RNA is capable of encoding diverse regulatory functions and is now known to be a critical regulator in all three domains of life. In examples ranging from riboswitches in bacteria to microRNAs in animals, regulatory RNAs orchestrate processes ranging from metabolism to development. However, our knowledge of the regulatory properties and roles played by these RNAs is still developing. In my research, I hope to better understand the natural utilization of RNA and translate insights into the programming of biological systems. By exploiting the natural utilization of RNA, I aim to implement RNA in ways already discovered and refined through evolution.


=Publications=
=Publications=


<biblio>
<biblio>
#beisel4 Beisel CL and Smolke CD. ''Design principles for riboswitch function.'' PLoS Comput Biol 2009 (accepted).
#beisel5 pmid=19381267
#beisel4 pmid=19118500
#beisel3 pmid=18956013
#beisel3 pmid=18956013
#beisel2 pmid=11852272
#beisel2 Beisel CL, Dowd MK, and Reilly PJ. ''Conformational analysis of gossypol and its derivatives by molecular mechanics.'' J Mol Struct THEOCHEM 2005; 730 51-58.
</biblio>
#beisel1 pmid=11852272
<biblio>
#beisel1 Beisel CL, Dowd MK, and Reilly PJ. ''Conformational analysis of gossypol and its derivatives by molecular mechanics.'' J Mol Struct THEOCHEM 2005; 730 51-58.
</biblio>
</biblio>

Latest revision as of 12:22, 18 July 2009

Chase Beisel

email: beiselcl@mail.nih.gov

phone: 301-496-4722

I am a postdoctoral fellow in Gisela Storz's group at the National Institute of Child Health and Human Development. My research currently focuses on studying the regulatory characteristics of bacterial small RNAs in stress responses. Prior to joining the Storz group, I was a graduate student in Christina Smolke's group at Caltech.

During my undergraduate days at Iowa State University, I worked in the groups of Peter Reilly, Jacqueline Shanks, and Charles Glatz. I was also an active member of the Iowa State Drumline.

Research Interests

I am interested in the regulatory capacity of RNA and how RNA can be exploited to program biological systems. RNA is capable of encoding diverse regulatory functions and is now known to be a critical regulator in all three domains of life. In examples ranging from riboswitches in bacteria to microRNAs in animals, regulatory RNAs orchestrate processes ranging from metabolism to development. However, our knowledge of the regulatory properties and roles played by these RNAs is still developing. In my research, I hope to better understand the natural utilization of RNA and translate insights into the programming of biological systems. By exploiting the natural utilization of RNA, I aim to implement RNA in ways already discovered and refined through evolution.

Publications

  1. Beisel CL and Smolke CD. Design principles for riboswitch function. PLoS Comput Biol. 2009 Apr;5(4):e1000363. DOI:10.1371/journal.pcbi.1000363 | PubMed ID:19381267 | HubMed [beisel5]
  2. Bayer TS, Hoff KG, Beisel CL, Lee JJ, and Smolke CD. Synthetic control of a fitness tradeoff in yeast nitrogen metabolism. J Biol Eng. 2009 Jan 2;3:1. DOI:10.1186/1754-1611-3-1 | PubMed ID:19118500 | HubMed [beisel4]
  3. Beisel CL, Bayer TS, Hoff KG, and Smolke CD. Model-guided design of ligand-regulated RNAi for programmable control of gene expression. Mol Syst Biol. 2008;4:224. DOI:10.1038/msb.2008.62 | PubMed ID:18956013 | HubMed [beisel3]
  4. Beisel CL, Dowd MK, and Reilly PJ. Conformational analysis of gossypol and its derivatives by molecular mechanics. J Mol Struct THEOCHEM 2005; 730 51-58.

    [beisel2]
  5. Judice TN, Nelson NC, Beisel CL, Delimont DC, Fritzsch B, and Beisel KW. Cochlear whole mount in situ hybridization: identification of longitudinal and radial gradients. Brain Res Brain Res Protoc. 2002 Feb;9(1):65-76. DOI:10.1016/s1385-299x(01)00138-6 | PubMed ID:11852272 | HubMed [beisel1]

All Medline abstracts: PubMed | HubMed