User:Cbeisel
Chase Beisel
email: cbeisel@caltech.edu
phone: 626-395-2680
mail: MC 210-41 Pasadena, CA 91125
I am currently a chemical engineering graduate student in Christina Smolke's group at Caltech.
During my undergraduate days of old, I attended Iowa State University and worked in the labs of Peter Reilly and Jacqueline Shanks. I was also an active member of the Iowa State Drumline.
Research Interests
Organisms have found truly exceptional ways to translate a set of basic biomolecules into robust, interacting networks of finely-tuned components. I am interested in studying the available design space of biomolecules in a cellular environment by engineering devices at the molecular scale to produce defined phenotypic responses. Currently, I am exploring the combination of substrates of RNA interference and RNA aptamers to generate molecules that can survey the cellular environment and regulate gene expression accordingly. In the future, I hope to incorporate these molecules into endogenous genetic networks and explore their effectiveness.
Publications
- Beisel CL, Bayer TS, Hoff KG, and Smolke CD. Model-guided design of ligand-regulated RNAi for programmable control of gene expression. Mol Syst Biol. 2008;4:224. DOI:10.1038/msb.2008.62 |
- Judice TN, Nelson NC, Beisel CL, Delimont DC, Fritzsch B, and Beisel KW. Cochlear whole mount in situ hybridization: identification of longitudinal and radial gradients. Brain Res Brain Res Protoc. 2002 Feb;9(1):65-76. DOI:10.1016/s1385-299x(01)00138-6 |
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Beisel CL, Dowd MK, and Reilly PJ. Conformational analysis of gossypol and its derivatives by molecular mechanics. J Mol Struct THEOCHEM 2005; 730 51-58.
