User:Cecilia Cisar/Notebook/Mod 3 Research Proposal

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==Project Description/Abstract==
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==Project Description==
* To design bacteria that use specific miRNA signatures to target cancer cells.
* To design bacteria that use specific miRNA signatures to target cancer cells.
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* [[20.109%28S14%29:Module_3_oral_presentations | Overview for this assignment and FAQ]]
==Overview==
==Overview==
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* During certain stages of growth, cancer cells exhibit unique miRNA signatures.<cite>Calin, George A., and Carlo M. Croce. "MicroRNA signatures in human cancers." Nature Reviews Cancer 6.11 (2006): 857-866.</cite>
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* MiRNAs are believed to be important in oncogenesis, as different groups of miRNAs act as either tumor suppressors or oncogenes. Changes in miRNA expression have been detected in many types of human cancers, in a way that seems to be linked to genomic amplifications, mutations, and deletions. "MiRNA expression fingerprints correlate with clinical and biological characteristics of tumours, including tissue type, differentiation, aggression and response to therapy." [1]
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* Some organisms use miRNA to target and inhibit sections of bacterial DNA.<cite>Ma, Feng, et al. "The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-[gamma]."Nature immunology 12.9 (2011): 861-869.</cite>
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* Some organisms use miRNA to target and inhibit sections of bacterial DNA. [2]
==References==
==References==
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<references />
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# [http://www.gene-quantification.eu/nature-reviews-microrna-3.pdf Calin, George A., and Carlo M. Croce. "MicroRNA signatures in human cancers." Nature Reviews Cancer 6.11 (2006): 857-866.]
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# [http://download.bioon.com.cn/view/upload/201110/19180817_1775.pdf Ma, Feng, et al. "The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ."Nature immunology 12.9 (2011): 861-869.]
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Revision as of 19:29, 5 May 2014

Project Description

Overview

  • MiRNAs are believed to be important in oncogenesis, as different groups of miRNAs act as either tumor suppressors or oncogenes. Changes in miRNA expression have been detected in many types of human cancers, in a way that seems to be linked to genomic amplifications, mutations, and deletions. "MiRNA expression fingerprints correlate with clinical and biological characteristics of tumours, including tissue type, differentiation, aggression and response to therapy." [1]
  • Some organisms use miRNA to target and inhibit sections of bacterial DNA. [2]

References

  1. Calin, George A., and Carlo M. Croce. "MicroRNA signatures in human cancers." Nature Reviews Cancer 6.11 (2006): 857-866.
  2. Ma, Feng, et al. "The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ."Nature immunology 12.9 (2011): 861-869.

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