User:Cecilia Cisar/Notebook/Mod 3 Research Proposal

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Project Description/Abstract

  • To design bacteria that use specific miRNA signatures to target cancer cells.

Overview

  • During certain stages of growth, cancer cells exhibit unique miRNA signatures.<ref>Calin, George A., and Carlo M. Croce. "MicroRNA signatures in human cancers." Nature Reviews Cancer 6.11 (2006): 857-866.</ref>
  • Some organisms use miRNA to target and inhibit sections of bacterial DNA.<ref>Ma, Feng, et al. "The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-[gamma]."Nature immunology 12.9 (2011): 861-869.</ref>


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