User:Cecilia Cisar/Notebook/Mod 3 Research Proposal: Difference between revisions
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**Would saying that there ''should'' be nothing wrong with the chassis and that it'll have to go through clinical testing be enough? | **Would saying that there ''should'' be nothing wrong with the chassis and that it'll have to go through clinical testing be enough? | ||
*Targeting of cancer cells | *Targeting of cancer cells | ||
** | **Bacteria do not specifically target things based on miRNA signatures | ||
**Could we rely on bacteria to stay localized, depending on treatment method? | **Could we rely on bacteria to stay localized, depending on treatment method? | ||
**Would regulation of oncogenes in non-target area be an issue? I want to think it would just make cancer-causing mutations even ''less'' likely in affected areas, even if they were not cancerous in the first place... | **Would regulation of oncogenes in non-target area be an issue? I want to think it would just make cancer-causing mutations even ''less'' likely in affected areas, even if they were not cancerous in the first place... | ||
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# [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570098/ Navarro, Lionel, et al. "Suppression of the microRNA pathway by bacterial effector proteins." Science 321.5891 (2008): 964-967.] | # [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570098/ Navarro, Lionel, et al. "Suppression of the microRNA pathway by bacterial effector proteins." Science 321.5891 (2008): 964-967.] | ||
# [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567904/?report=reader Taganov, Konstantin D., et al. "NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses." Proceedings of the National Academy of Sciences 103.33 (2006): 12481-12486.] | # [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567904/?report=reader Taganov, Konstantin D., et al. "NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses." Proceedings of the National Academy of Sciences 103.33 (2006): 12481-12486.] | ||
# [http://onlinelibrary.wiley.com/doi/10.1002/ijc.25284/full Kano, M., Seki, N., Kikkawa, N., Fujimura, L., Hoshino, I., Akutsu, Y., Chiyomaru, T., Enokida, H., Nakagawa, M. and Matsubara, H. (2010), miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma. Int. J. Cancer, 127: 2804–2814.] | |||
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Latest revision as of 09:09, 7 May 2014
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