User:Cecilia Cisar/Notebook/Mod 3 Research Proposal

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(Project Description/Abstract)
(Overview)
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==Overview==
==Overview==
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* During certain stages of growth, cancer cells exhibit unique miRNA signatures.<sup>[1]</sup>
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* MiRNAs are believed to be important in oncogenesis, as different groups of miRNAs act as either tumor suppressors or oncogenes.  Changes in miRNA expression have been detected in many types of human cancers, in a way that seems to be linked to genomic amplifications, mutations, and deletions.<sup>[1]</sup>
* Some organisms use miRNA to target and inhibit sections of bacterial DNA.<sup>[2]</sup>
* Some organisms use miRNA to target and inhibit sections of bacterial DNA.<sup>[2]</sup>

Revision as of 18:23, 5 May 2014

Project Description

Overview

  • MiRNAs are believed to be important in oncogenesis, as different groups of miRNAs act as either tumor suppressors or oncogenes. Changes in miRNA expression have been detected in many types of human cancers, in a way that seems to be linked to genomic amplifications, mutations, and deletions.[1]
  • Some organisms use miRNA to target and inhibit sections of bacterial DNA.[2]

References

  1. Calin, George A., and Carlo M. Croce. "MicroRNA signatures in human cancers." Nature Reviews Cancer 6.11 (2006): 857-866.
  2. Ma, Feng, et al. "The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ."Nature immunology 12.9 (2011): 861-869.

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