User:Cecilia Cisar/Notebook/Mod 3 Research Proposal

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Project Description/Abstract

  • To design bacteria that use specific miRNA signatures to target cancer cells.

Overview

  • During certain stages of growth, cancer cells exhibit unique miRNA signatures.[1]
  • Some organisms use miRNA to target and inhibit sections of bacterial DNA.[2]

References

  1. Calin, George A., and Carlo M. Croce. "MicroRNA signatures in human cancers." Nature Reviews Cancer 6.11 (2006): 857-866.
  2. Ma, Feng, et al. "The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ."Nature immunology 12.9 (2011): 861-869.
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