User:Cecilia Cisar/Notebook/Mod 3 Research Proposal

Project Description To design bacteria that use specific miRNA signatures to target cancer cells. Overview for this assignment and FAQ Overview MiRNAs are believed to be important in oncogenesis, as different groups of miRNAs act as either tumor suppressors or oncogenes. Changes in miRNA expression have been detected in many types of human cancers, in a way that seems to be linked to genomic amplifications, mutations, and deletions.[1] Some organisms use miRNA to target and inhibit sections of bacterial DNA.[2] References Calin, George A., and Carlo M. Croce. "MicroRNA signatures in human cancers." Nature Reviews Cancer 6.11 (2006): 857-866. Ma, Feng, et al. "The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ."Nature immunology 12.9 (2011): 861-869.

Recently Edited Notebook Pages 2017-09-26 23:56:17 User:Cecilia Cisar/Notebook/Mod 3 Research Proposal/Entry Base