User:Chang-Hun Lee

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Chang-Hun Lee

College of Basic Science, School of Convergence, DGIST

E-Mail : thefifthnetizen@daum.net

Research interests

Structure-Function of Intermediate Filament Proteins

• Keratin
• Skin epithelia
• Molecular mechanism of skin blistering disease, Epidermolysis Bullosa Symplex

Protein chemistry

Education and Professional Training

• 1996 - 2000  : B.Sci.(Biology)/B.Sci.(Biochemistry) (Yonsei University, Seoul, Korea)

• 2000 - 2001  : Research assistant (SBMB laboratory, Yonsei University (P.I.: Wontae Lee, Ph.D.))

• 2001 - 2002  : Legal Assistant (Kim & Chang Intellectual Property)

• 2002 - 2009 : Ph.D graduate program (Department of Biological Chemistry, Johns Hopkins, School of Medicine)

• 2009 - 2012 : Post-Doc ((Dr. Pierre Coulombe Lab), Department of Biochemistry and Molecular Biology, Johns Hopkins, BloombergSchool of Public Health)

Honors and Awards

Poster Award(2012) 5th Annual Conference of Baltimore Life Scientists Association

Award for the Best Research Project (2000) Korean Society for Biochemistry and Molecular Biology

Publications

1. Lee CH, Hong H, Shin J, Jung M, Shin I, Yoon J, Lee W. NMR studies on novel antitumor drug candidates, deoxoartemisinin and carboxypropyldeoxoartemisinin. Biochem Biophys Res Commun. 2000 Aug 2;274(2):359-369.
2. Lim S, Li S, Lee C, Yoon C, Baik J, Lee W. Minimization of MC1R selectivity by modification of the core structure of alpha-MSH-ND. Chem Biol. 2001 Sep;8(9):857-870.
3. Bang E, Lee CH, Yoon JB, Lee DW, Lee W. Solution structures of the N-terminal domain of histone H4. J Pept Res. 2001 Nov;58(5):389-398.
4. Yee A, Chang X, Pineda-Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee GM, Bhattacharyya S, Gutierrez P, Denisov A, Lee CH, Cort JR, Kozlov G, Liao J, Finak G, Chen L, Wishart D, Lee W, McIntosh LP, Gehring K, Kennedy MA, Edwards AM, Arrowsmith CH. An NMR approach to structural proteomics. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1825-1830.
5. Jang HJ, Lee CH, Lee W, Kim YS. Two flexible loops in subtilisin-like thermophilic protease, thermicin, from Thermoanaerobacter yonseiensis. J Biochem Mol Biol. 2002 Sep 30;35(5):498-507.
6. Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W. Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum. Protein Sci. 2004 Apr;13(4):1148-1154.
7. Bernot KM, Lee CH, Coulombe PA. A small surface hydrophobic stripe in the coiled-coil domain of type I keratins mediates tetramer stability. J Cell Biol. 2005 Mar 14;168(6):965-74.
8. Cho MK, Lee CJ, Lee CH, Li SZ, Lim SK, Baik JH, Lee W. Structure and function of the potent cyclic and linear melanocortin analogues. J Struct Biol. 2005 Jun;150(3):300-308.
9. Kim S, Kellner J, Lee CH, Coulombe PA. Interaction between the keratin cytoskeleton and eEF1Bgamma affects protein synthesis in epithelial cells. Nat Struct Mol Biol. 2007 Oct;14(10):982-983.
10. Lee CH, and Coulombe PA. Self-organization of keratin intermediate filaments into cross-linked networks. J Cell Biol. 2009 Aug;186(3):409-421.
11. Kim JS, Lee CH, and Coulombe PA. Modeling the self-organization property of keratin intermediate filaments. Biophys J. 2010 Nov;99(9):2748-2756.
12. Coulombe PA and Lee CH. Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath. J Invest Dermatol. 2012 March;132(3 Pt 2):763-775.
13. Lee CH, Kim MS, Chung BM, Leahy DJ and Coulombe PA. Structural Basis of Heteromerization and Perinuclear Organization of Keratin Filaments. Nat Struct Mol Biol. 2012 June;19(7):707-715.

Personal interests

• Flurorescence of biomolecules
• Bioluminescence : See Wikipedia or A good web page
• Astrobiology
• Astronomy picture of the day
• Waterlife
• Kumdo

Group Activities

• BLSA
• JHIBRG