User:Chris

Education & Training

• Undergraduate Major: Molecular & Cell Biology at the Univ. of California, Berkeley

• Graduate School: Ph.D. Biochemistry and Molecular Biology completed in the Rotwein Lab of the Dep't of Biochemistry & Molecular Biology at Oregon Health & Science Univ.

• Medical School: M.D. at Oregon Health & Science University with the OHSU MD/PhD Program

• Residency: Duke Department of Pediatrics

• Currently a Clinical Associate (Pediatrics Hospitalist) for the Duke Pediatrics Division of Blood & Bone Marrow Transplantation Program.

Pediatric Medicine Links

• Acute Otitis Media AOM videos by the AAP

• Back to Sleep Campaign to decrease incidence of SIDS and video for parents

• Perspectives in patient care video, and children with autism video when they grow up.

• Newborn Photo Library from Lucile Packard Children's Hospital (LPCH)

• An excellent resource on feeding your infant by Jane Morton, MD: Tips on Successful Breastfeeding and for babies at high risk (e.g., in the NICU / ICN)

• Echocardiography in the ICU and Animated Heart Anatomy

• Immunizations & Public Health (Vaccine Information)

• Car Seat Safety and what you can do to keep your children safe in the car (another Car Seat site by SaferCar.gov).

• Dermatology Module from Univ. Wisconsin

• Calculators:
• NICHD Neonatal Research Network (NRN): Extremely Preterm Birth Outcome Data Neonate Calculator
• Kawasaki Disease Calculator and the original paper in The Journal of Pediatrics.
• The Newborn Weight Tool NEWT from Pen State Medical Center

Organizations and links to Pediatric Health Care

• Duke Pediatrics and Pediatrics Residency Program at Duke University

• Doernbecher Children’s Hospital @ OHSU

• A great App from Doernbecher for parents: iPhone MD4Kids (or MD4kids android devices)

• Helping Children love books from the start with East Bay Children’s Book Project and the National Reach out and Read program.

• Children’s Hospital Oakland and CHORI (Research Institute) including links to the Comprehensive Thalassemia Center

• UCSF Children’s Hospital including some great ways to talk to your children about an upcoming hospitalization.

• Packard Kids Connection @ LPCH, a great interactive site explaining select medical procedures to children and their parents (in English or Spanish), along with the “Power Penguin.”

• Seattle Children’s Hospital, SCH's on-line Grand Rounds, and Meet a Scientist from Seattle Children's Hospital, "Adventure Lab."

• Children's Hospital Boston, including the literature character "Arthur's Guide" to Children's Hospital.

• The American Academy of Pediatrics including Pediatrics in Review

Research

• 2003-04, a BioMedical Staff Scientist in the BBRP (now the Physical and Life Sciences Directorate) at Lawrence Livermore National Laboratory.

• 2005-2010 Graduate Student at OHSU

Research Interests:

I study the regulation of a gene called RGMc (also called Hemojuvelin (HJV) in humans). RGMc/HJV plays a critical role in iron metabolism, as inactivating mutations cause juvenile hemochromatosis, a severe iron overload disorder.

The long-range goals of my research are to enhance understanding of the molecular mechanisms by which evolution has shaped the regulation of gene expression in a family of genes, and apply this knowledge to understand select human diseases.

The primary focus of my research is three-fold:

(1) to understand the genomic structure of the Repulsive Guidance Molecule (RGM) family,

(2) to understand the mechanisms of transcriptional regulation of RGMc,

(3) to understand the basics of the molecular evolution of the RGM family.

An interactive Molecular Model of the RGM-family at the protein level

For the Transcriptional Regulation of RGMc, see this 2010 article in Genomics.

More Coming soon!

General Scientific Links (a.k.a., Teaching Science in the Community):

• Understanding Evolution and why its so important to health, disease, and our fundamental understanding of biology.

• Exploring the microbiome in each of us.

• The Microbiome explained in cartoon form.

• Genome Glossary

• Learn Genetics with videos and interactive lessons.

• Learn how fundamental science uncovered our understanding of "How the Brain and Nervous System work".

• Introduction to X-ray Crystallography. An easy to understand video going from cells to structure.

• "Mini Med-School" lecture by Robert H. Lustig, MD, UCSF Professor of Pediatrics in the Division of Endocrinology, explores the damage caused by sugary foods. He argues that (too much) fructose and (not enough) fiber appear to be cornerstones of the obesity epidemic through their effects on insulin. Series: UCSF Mini Medical School for the Public (7/2009; Health and Medicine, Show ID: 16717)

• Tree of Life web project about biodiversity.

• Learn about RNAi and gene regulation, with "a petunia, Pirate Ships, little Chefs, and 'the Cop'." (Intrigued? Click on the link and watch the video)

• Want to know what Nanotechnology is? Find out in three minutes with the Nanosong by students at Cal.

• The Powers of 10 expolores the range of sizes in our world, and our perspective in it. “We find that we inhabit an insignificant planet of a hum-drum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.” -Carl Sagan

• Learn about insects with "The Bug Chicks", from Portland, Oregon.

• Meet a Scientist from Seattle Children's Hospital, "Adventure Lab."

• Two songs about The Elements: (1) They Might Be Giants and (2) Tom Lehrer's "The Elements"

More soon!

Publications

All Publications for C.J. Severyn on NCBI-PubMed

ResearcherID Link for C. Severyn

1. Molecular biology, genetics and biochemistry of the repulsive guidance molecule family.

C. J. Severyn, U. Shinde and P. Rotwein, Biochem. J. (2009) v422:393-403 [1]

2. Conserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin (Hfe2) gene transcription in skeletal muscle.

C. J. Severyn and P. Rotwein, Genomics (2010) v96:342–351 [2]

3. PhD Dissertation: Regulation and evolutionary origins of repulsive guidance molecule C / hemojuvelin expression : a muscle-enriched gene involved in iron metabolism

C. J. Severyn, OHSU Digital Commons (July 2010)[3]

Photography

See some of my photographs including this image of Mount Hood in Oregon:

WebCams and other links

• “The View” from the hills of the Greatest University in the World

• OHSU Cameras in Portland, OR

• Monterey Bay Aquarium Web-Cams

• Farallones Cam

• Watch the new Bay Bridge construction

• Falcon-Cam: “Clara,” the Peregrine Falcon

• A web-based version to plan your visit to one of "America's Best Idea"

• And more views from the webcams at Yosemite National Park

• Or the eastern side of the Sierra Nevada with Mono Lake

• A time-lapse video of one of the greatest locations on the planet, and the sequel.

• An archive of the development of the 1960 Master Plan for Higher Education in California and how Public Education & Health should be at the forefront of our society. It begins with providing access to a world-class education for students of all means, and then moving forward to improve our society at the level of the State, the Nation, and the World.

OHSU 2007 Course: Adv. Topics in Molecular Biology

Discussion Questions and Presentations: Chris

DNA Replication Discussion Qsts

Exon Junction Complex BMCB625:Exon_Jxn_Complex

Link to Universal Template BMCB625:Discussion_Univ_template

Mathematics in Biology BMCB625:Mathematics_in_Biology