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Christopher Severyn




Major: Molecular & Cell Biology at the Univ. of California, Berkeley


  • Currently a Graduate Student at OHSU (See "Current" below)


7th year student in OHSU's MD/PhD Program (MS2)

Graduate Student in the Rotwein Lab of the Dep't of Biochemistry & Molecular Biology at Oregon Health & Science Univ.

Research Interests:

I study the regulation of a gene called RGMc (also called Hemojuvelin (HJV) in humans). RGMc/HJV plays a critical role in iron metabolism, as inactivating mutations cause juvenile hemochromatosis, a severe iron overload disorder.

The long-range goal of my research is to enhance understanding of the molecular mechanisms by which evolution has shaped the regulation of gene expression in a family of genes.

The primary focus of my research is three-fold:

(1) to understand the genomic structure of the Repulsive Guidance Molecule (RGM) family,

(2) to understand the mechanisms of transcriptional regulation of RGMc,

(3) to understand the basics of the molecular evolution of the RGM family.

An interactive Molecular Model of the RGM-family at the protein level

For the Transcriptional Regulation of RGMc, see this new paper in Genomics.

More Coming soon!

General Scientific Links (a.k.a., Teaching Science in the Community):

  • Understanding Evolution and why its so important to health, disease, and our fundamental understanding of biology.
  • "Mini Med-School" lecture by Robert H. Lustig, MD, UCSF Professor of Pediatrics in the Division of Endocrinology, explores the damage caused by sugary foods. He argues that (too much) fructose and (not enough) fiber appear to be cornerstones of the obesity epidemic through their effects on insulin. Series: UCSF Mini Medical School for the Public (7/2009; Health and Medicine, Show ID: 16717)
  • Learn about RNAi and gene regulation, with "a petunia, Pirate Ships, little Chefs, and 'the Cop'." (Intrigued? Click on the link and watch the video)
  • The Powers of 10 expolores the range of sizes in our world, and our perspective in it. “We find that we inhabit an insignificant planet of a hum-drum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.” -Carl Sagan

More soon!


All Publications for C.J. Severyn on NCBI-PubMed

ResearcherID Link for C. Severyn

1. Molecular biology, genetics and biochemistry of the repulsive guidance molecule family. C. J. Severyn, U. Shinde and P. Rotwein, Biochem. J. (2009) v422:393-403 [1]

2. Conserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin gene transcription in skeletal muscle. C. J. Severyn and P. Rotwein, Genomics (2010) in Press


email: severync AT ohsu DOT edu

WebCams and other links

  • Or the eastern side of the Sierra Nevada with Mono Lake


  • Packard Kids Connection @ LPCH, a great interactive site explaining select medical procedures to children and their parents (in English or Spanish), along with the “Power Penguin.”

Why drive when you bike or fly: also known as ‘When in Portland’

Portland Area Maps

‘I want to ride my bicycle,’ and all things cycling related in Portland, OR

Airports accessible by MAX light rail HIO and PDX

Other flight tools: RunwayFinder, SkyVector at PDX, and AirNav_PDX

Course Web Pages

OHSU 2007 Course: Adv. Topics in Molecular Biology

BMCB625 Advanced Topics in Molecular Biology

Home        People        Materials        Schedule        Help        Discussion       

Discussion Questions and Presentations: Chris

DNA Replication Discussion Qsts
Exon Junction Complex BMCB625:Exon_Jxn_Complex
Link to Universal Template BMCB625:Discussion_Univ_template
Mathematics in Biology BMCB625:Mathematics_in_Biology
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