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==About Me==
==About Me==
I recently completed a post-doc as Detector Layer team leader for the MIT RealNose project, a DARPA-funded effort to engineer a  
I recently completed a post-doc as Detector Layer team leader for the MIT RealNose project, a DARPA-funded effort to engineer a biologically-based smell sensor utilizing olfactory receptor proteins.  
biologically-based smell sensor utilizing olfactory receptor proteins.  


I've also enjoyed synthetic biology tinkering as a Graduate Advisor to the 2007 and 2008 MIT iGEM teams. For more info on iGEM, check out:  
I've also enjoyed synthetic biology tinkering as a Graduate Advisor to the 2007 and 2008 MIT iGEM teams. For more info on iGEM, check out:  
  [[IGEM:MIT/2007 |the 2007 MIT iGEM Page!]]  
  [[IGEM:MIT/2007 |the 2007 MIT iGEM Page!]]  
  [[IGEM:MIT/2008 |the 2008 MIT iGEM Page|]]   
  [[IGEM:MIT/2008 |the 2008 MIT iGEM Page|]]   

Revision as of 19:22, 12 November 2009

My Info

Brian L. Cook, Ph.D.

Email: cookb@mit.edu

MIT Biological Engineering
Zhang Lab (Center for Biomedical Engineering)
500 Technology Square -- NE47-380
Cambridge, MA 02139

About Me

I recently completed a post-doc as Detector Layer team leader for the MIT RealNose project, a DARPA-funded effort to engineer a biologically-based smell sensor utilizing olfactory receptor proteins.

I've also enjoyed synthetic biology tinkering as a Graduate Advisor to the 2007 and 2008 MIT iGEM teams. For more info on iGEM, check out:

the 2007 MIT iGEM Page! 
the 2008 MIT iGEM Page|  
Official iGEM website

Publications

  1. Cook BL, Steuerwald D, Kaiser L, Graveland-Bikker J, Vanberghem M, Berke AP, Herlihy K, Pick H, Vogel H, and Zhang S. Large-scale production and study of a synthetic G protein-coupled receptor: human olfactory receptor 17-4. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11925-30. DOI:10.1073/pnas.0811089106 | PubMed ID:19581598 | HubMed [cookb2009a]
  2. Ren H, Yu D, Ge B, Cook B, Xu Z, and Zhang S. High-level production, solubilization and purification of synthetic human GPCR chemokine receptors CCR5, CCR3, CXCR4 and CX3CR1. PLoS One. 2009;4(2):e4509. DOI:10.1371/journal.pone.0004509 | PubMed ID:19223978 | HubMed [cookb2009b]
  3. Jiang X, Austin PF, Niederhoff RA, Manson SR, Riehm JJ, Cook BL, Pengue G, Chitaley K, Nakayama K, Nakayama KI, and Weintraub SJ. Mechanoregulation of proliferation. Mol Cell Biol. 2009 Sep;29(18):5104-14. DOI:10.1128/MCB.00465-09 | PubMed ID:19596792 | HubMed [cookb2009c]
  4. Cook BL, Ernberg KE, Chung H, and Zhang S. Study of a synthetic human olfactory receptor 17-4: expression and purification from an inducible mammalian cell line. PLoS One. 2008 Aug 6;3(8):e2920. DOI:10.1371/journal.pone.0002920 | PubMed ID:18682799 | HubMed [cookb2008]
  5. Austin PF, Cook BL, Niederhoff RA, Manson SR, Coplen DE, and Weintraub SJ. Inhibition of mitogenic signaling and induction of apoptosis in human bladder smooth muscle cells treated with doxazosin. J Urol. 2004 Oct;172(4 Pt 2):1662-5; discussion 1666. DOI:10.1097/01.ju.0000138524.18870.af | PubMed ID:15371785 | HubMed [cookb2004]
  6. Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosová I, Kulans LA, Fu X, Weinberg JS, Heinecke JW, Roth KA, and Weintraub SJ. Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell. 2002 Oct 4;111(1):51-62. DOI:10.1016/s0092-8674(02)00972-8 | PubMed ID:12372300 | HubMed [cookb2002]
  7. He S, Cook BL, Deverman BE, Weihe U, Zhang F, Prachand V, Zheng J, and Weintraub SJ. E2F is required to prevent inappropriate S-phase entry of mammalian cells. Mol Cell Biol. 2000 Jan;20(1):363-71. DOI:10.1128/MCB.20.1.363-371.2000 | PubMed ID:10594038 | HubMed [cookb2000]

All Medline abstracts: PubMed | HubMed

References

Shuguang Zhang, Ph.D.

Associate Director, MIT Center for Biomedical Engineering
500 Technology Square, NE47-379
Cambridge, MA 02139
Phone: (617) 258-7514		
Fax:   (617) 258-5239
Email: shuguang@mit.edu

Andreas Mershin, Ph.D.

MIT RealNose Project Manager, MIT Center for Biomedical Engineering
500 Technology Square, NE47-383
Cambridge, MA 02139
Phone: (617) 515-4192
Fax:   (617) 258-5239
Email: mershin@mit.edu

Steven J. Weintraub, M.D.

Department of Internal Medicine 
St. Louis VA Medical Center–John Cochran Division 
915 North Grand Blvd 
Saint Louis, Missouri 63106 
Phone: (314) 652-4100 x55298 
Email: sjweintraub@gmail.com