User:Cookb

My Info

Brian L. Cook, Ph.D.

Email: cookb@mit.edu

MIT Biological Engineering
Zhang Lab (Center for Biomedical Engineering)
500 Technology Square -- NE47-380
Cambridge, MA 02139

About Me

I recently completed a post-doc as Detector Layer team leader for the MIT RealNose project, a DARPA-funded effort to engineer a biologically-based smell sensor utilizing olfactory receptor proteins.

I've also enjoyed synthetic biology tinkering as a Graduate Advisor to the 2007 and 2008 MIT iGEM teams. For more info on iGEM, check out:

 the 2007 MIT iGEM Page! 
 the 2008 MIT iGEM Page|  
 Official iGEM website

Publications

1. Cook BL, Steuerwald D, Kaiser L, Graveland-Bikker J, Vanberghem M, Berke AP, Herlihy K, Pick H, Vogel H, and Zhang S. Large-scale production and study of a synthetic G protein-coupled receptor: human olfactory receptor 17-4. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11925-30. DOI:10.1073/pnas.0811089106 |
2. Ren H, Yu D, Ge B, Cook B, Xu Z, and Zhang S. High-level production, solubilization and purification of synthetic human GPCR chemokine receptors CCR5, CCR3, CXCR4 and CX3CR1. PLoS One. 2009;4(2):e4509. DOI:10.1371/journal.pone.0004509 |
3. Jiang X, Austin PF, Niederhoff RA, Manson SR, Riehm JJ, Cook BL, Pengue G, Chitaley K, Nakayama K, Nakayama KI, and Weintraub SJ. Mechanoregulation of proliferation. Mol Cell Biol. 2009 Sep;29(18):5104-14. DOI:10.1128/MCB.00465-09 |
4. Cook BL, Ernberg KE, Chung H, and Zhang S. Study of a synthetic human olfactory receptor 17-4: expression and purification from an inducible mammalian cell line. PLoS One. 2008 Aug 6;3(8):e2920. DOI:10.1371/journal.pone.0002920 |
5. Austin PF, Cook BL, Niederhoff RA, Manson SR, Coplen DE, and Weintraub SJ. Inhibition of mitogenic signaling and induction of apoptosis in human bladder smooth muscle cells treated with doxazosin. J Urol. 2004 Oct;172(4 Pt 2):1662-5; discussion 1666. DOI:10.1097/01.ju.0000138524.18870.af |
6. Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosová I, Kulans LA, Fu X, Weinberg JS, Heinecke JW, Roth KA, and Weintraub SJ. Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell. 2002 Oct 4;111(1):51-62. DOI:10.1016/s0092-8674(02)00972-8 |
7. He S, Cook BL, Deverman BE, Weihe U, Zhang F, Prachand V, Zheng J, and Weintraub SJ. E2F is required to prevent inappropriate S-phase entry of mammalian cells. Mol Cell Biol. 2000 Jan;20(1):363-71. DOI:10.1128/MCB.20.1.363-371.2000 |

References

Shuguang Zhang, Ph.D.

• Associate Director, MIT Center for Biomedical Engineering
• 500 Technology Square, NE47-379
• Cambridge, MA 02139
• Phone: (617) 258-7514
• Fax: (617) 258-5239
• Email: shuguang@mit.edu

Andreas Mershin, Ph.D.

MIT RealNose Project Manager, MIT Center for Biomedical Engineering

500 Technology Square, NE47-383

Cambridge, MA 02139

Phone: (617) 515-4192

Fax: (617) 258-5239

Email: mershin@mit.edu

Steven J. Weintraub, M.D.

Department of Internal Medicine

St. Louis VA Medical Center–John Cochran Division

915 North Grand Blvd

Saint Louis, Missouri 63106

Phone: (314) 652-4100 x55298

Email: sjweintraub@gmail.com