User:Damian Ekiert
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Damian C. Ekiert PhD Candidate
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I am a graduate student in the Wilson Lab at The Scripps Research Institute.
Research Interests
- Neutralization of influenza viruses by antibodies
- Rational vaccine design guided by broadly neutralizing antibodies
- Diversity of antibody structure and function
Education
- 2011 (Expected), PhD, Scripps Research Institute
- 2005, B.A. in Biology, The University of Chicago
Past Lab Work
- 2007-2011: Prof. Ian A. Wilson Lab, thesis, structural characterization of broadly neutralizing antibodies against the influenza A virus.
- 2006-2007: Prof. Carlos Barbas Lab, graduate rotation, directed evolution of site specific recombinases for genome engineering and gene therapy.
- 2005-2006: Prof. Michael Glotzer Lab (gap year) working on cytokinesis in mammalian cells.
- 2003-2004: Prof. Miroslav Radman (Université Paris Descartes) and Prof. Masamichi Kohiyama (Université Pierre et Marie Curie) groups during year abroad in Paris, working on mismatch-stimulated killing and the localization of replication forks in E. coli.
- 2003-2005: Prof. Bernard Strauss Lab (University of Chicago), undergraduate honors thesis, investigating the coordination of DNA replication and cell division in E. coli.
Publications
- Wang TT, Tan GS, Hai R, Pica N, Ngai L, Ekiert DC, Wilson IA, García-Sastre A, Moran TM, Palese P. Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18979-84. PMID: 20956293
- Xu R *, Ekiert DC *, Krause JC, Hai R, Crowe JE Jr, Wilson IA. Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus. Science. 2010 Apr 16;328(5976):357-60. PMID: 20339031
- Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA. Antibody recognition of a highly conserved influenza virus epitope. Science. 2009 Apr 10;324(5924):246-51. PMID: 19251591
- Simon GC, Schonteich E, Wu CC, Piekny A, Ekiert D, Yu X, Gould GW, Glotzer M, Prekeris R. Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. EMBO J. 2008 Jul 9;27(13):1791-803. PMID: 18511905
- Matic I, Ekiert D, Radman M, Kohiyama M. Generation of DNA-free Escherichia coli cells by 2-aminopurine requires mismatch repair and nonmethylated DNA. J Bacteriol. 2006 Jan;188(1):339-42. PMID: 16352851
- Strauss B, Kelly K, Ekiert D. Cytochrome oxidase deficiency protects Escherichia coli from cell death but not from filamentation due to thymine deficiency or DNA polymerase inactivation. J Bacteriol. 2005 Apr;187(8):2827-35. PMID: 15805529
- Strauss B, Kelly K, Dincman T, Ekiert D, Biesieda T, Song R. Cell death in Escherichia coli dnaE(Ts) mutants incubated at a nonpermissive temperature is prevented by mutation in the cydA gene. J Bacteriol. 2004 Apr;186(7):2147-55. PMID: 15028700