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Revision as of 14:10, 12 October 2009
David J. Klinke II
Assistant Professor
Department of Chemical Engineering
Department of Microbiology, Immunology, and Cell Biology
West Virginia University
P.O. Box 6102
Morgantown, WV 26506-6102
david.klinke at mail.wvu.edu
Education and Industrial Experience
- 1999-2005, Biosystems Engineer, Entelos, Inc., Foster City, CA
- 1999, Post-Doctoral Fellow, Sandia National Laboratory, Livermore, CA
- 1998, PhD, Northwestern University, Evanston IL
- 1995, MS, Northwestern University, Evanston IL
- 1992, BS, Virginia Tech, Blacksburg, VA
Research interests
- Cellular Signal Transduction in Cancer and Immunology
- Proteomics and Flow Cytometry
- Bayesian statistics
Publications
- Klinke DJ 2nd and Brundage KM. Scalable analysis of flow cytometry data using R/Bioconductor. Cytometry A. 2009 Aug;75(8):699-706. DOI:10.1002/cyto.a.20746 |
Provides a tutorial for using R/Bioconductor to process flow cytometry data.
- Klinke DJ 2nd. Validating a dimensionless number for glucose homeostasis in humans. Ann Biomed Eng. 2009 Sep;37(9):1886-96. DOI:10.1007/s10439-009-9733-y |
Develops and validates a dimensionless number for the ratio of insulin production and insulin-dependent glucose metabolism in humans.
- Klinke DJ 2nd, Ustyugova IV, Brundage KM, and Barnett JB. Modulating temporal control of NF-kappaB activation: implications for therapeutic and assay selection. Biophys J. 2008 Jun;94(11):4249-59. DOI:10.1529/biophysj.107.120451 |
Finds that our ability to observe significant biological events is limited by the signal-to-noise characteristics of the assays that we use to observe cellular responses.
- Klinke DJ 2nd. Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus. PLoS One. 2008 Jan 2;3(1):e1374. DOI:10.1371/journal.pone.0001374 |
Evaluates the conventional wisdom regarding the extent of beta cell destruction required before presenting with symptoms of type 1 diabetes.
- Klinke DJ 2nd. Integrating epidemiological data into a mechanistic model of type 2 diabetes: validating the prevalence of virtual patients. Ann Biomed Eng. 2008 Feb;36(2):321-34. DOI:10.1007/s10439-007-9410-y |
Provides a glimpse of the kind of models developed by Entelos, Inc.
- Klinke DJ 2nd. A multi-scale model of dendritic cell education and trafficking in the lung: implications for T cell polarization. Ann Biomed Eng. 2007 Jun;35(6):937-55. DOI:10.1007/s10439-007-9318-6 |
- Klinke DJ 2nd. An age-structured model of dendritic cell trafficking in the lung. Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L1038-49. DOI:10.1152/ajplung.00048.2006 |
- Klinke DJ 2nd. The ratio of P40 monomer to dimer is an important determinant of IL-12 bioactivity. J Theor Biol. 2006 May 21;240(2):323-35. DOI:10.1016/j.jtbi.2005.09.022 |
Awards
- 1992 Summa cum laude alumnus, Commonweath Scholar, Virginia Tech
- 2008 - 2009 Research Starter Grant in Informatics