User:David J. Klinke II

David J. Klinke II

Assistant Professor
Department of Chemical Engineering
Department of Microbiology, Immunology, and Cell Biology
West Virginia University
P.O. Box 6102
Morgantown, WV 26506-6102

david.klinke at mail.wvu.edu

Education and Industrial Experience

• 1999-2005, Biosystems Engineer, Entelos, Inc., Foster City, CA
• 1999, Post-Doctoral Fellow, Sandia National Laboratory, Livermore, CA
• 1998, PhD, Northwestern University, Evanston IL
• 1995, MS, Northwestern University, Evanston IL
• 1992, BS, Virginia Tech, Blacksburg, VA

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Research interests

• Cellular Signal Transduction
• Proteomics
• Bayesian statistics

Publications

1. Klinke DJ 2nd and Brundage KM. Scalable analysis of flow cytometry data using R/Bioconductor. Cytometry A. 2009 Aug;75(8):699-706. DOI:10.1002/cyto.a.20746 |

   Provides a tutorial for using R/Bioconductor to process flow cytometry data.

2. Klinke DJ 2nd. Validating a dimensionless number for glucose homeostasis in humans. Ann Biomed Eng. 2009 Sep;37(9):1886-96. DOI:10.1007/s10439-009-9733-y |

   Develops and validates a dimensionless number for the ratio of insulin production and insulin-dependent glucose metabolism in humans.

3. Klinke DJ 2nd, Ustyugova IV, Brundage KM, and Barnett JB. Modulating temporal control of NF-kappaB activation: implications for therapeutic and assay selection. Biophys J. 2008 Jun;94(11):4249-59. DOI:10.1529/biophysj.107.120451 |

   Finds that our ability to observe significant biological events is limited by the signal-to-noise characteristics of the assays that we use to observe cellular responses.

4. Klinke DJ 2nd. Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus. PLoS One. 2008 Jan 2;3(1):e1374. DOI:10.1371/journal.pone.0001374 |

   Evaluates the conventional wisdom regarding the extent of beta cell destruction required before presenting with symptoms of type 1 diabetes.

5. Klinke DJ 2nd. Validating a dimensionless number for glucose homeostasis in humans. Ann Biomed Eng. 2009 Sep;37(9):1886-96. DOI:10.1007/s10439-009-9733-y |
6. Klinke DJ 2nd. Validating a dimensionless number for glucose homeostasis in humans. Ann Biomed Eng. 2009 Sep;37(9):1886-96. DOI:10.1007/s10439-009-9733-y |

   leave a comment about a paper here

Useful links

• Introductory tutorial
• OpenWetWare help pages