User:Denizkural
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=== COMIT: identification of noncoding motifs under selection in coding sequences === | === COMIT: identification of noncoding motifs under selection in coding sequences === | ||
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Coding nucleotide sequences contain myriad functions independent of their encoded protein sequences. We present the COMIT algorithm to detect functional noncoding motifs in coding regions using sequence conservation, explicitly separating nucleotide from amino acid effects. COMIT concurs with diverse experimental datasets, including splicing enhancers, silencers, replication motifs, and microRNA targets, and predicts many novel functional motifs. Intriguingly, COMIT scores are well-correlated to scores uncalibrated for amino acids, suggesting that nucleotide motifs often override peptide-level constraints. | Coding nucleotide sequences contain myriad functions independent of their encoded protein sequences. We present the COMIT algorithm to detect functional noncoding motifs in coding regions using sequence conservation, explicitly separating nucleotide from amino acid effects. COMIT concurs with diverse experimental datasets, including splicing enhancers, silencers, replication motifs, and microRNA targets, and predicts many novel functional motifs. Intriguingly, COMIT scores are well-correlated to scores uncalibrated for amino acids, suggesting that nucleotide motifs often override peptide-level constraints. | ||
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Deniz Kural, Yang Ding, Jiantao Wu, Alicia M Korpi and Jeffrey H Chuang | Deniz Kural, Yang Ding, Jiantao Wu, Alicia M Korpi and Jeffrey H Chuang | ||
| - | [http://genomebiology.com/2009/10/11/R133] (open access) | + | [http://genomebiology.com/2009/10/11/R133 http://genomebiology.com/2009/10/11/R133] (open access) |
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| + | Genome Biology 2009, 10:R133, | ||
| - | + | doi:10.1186/gb-2009-10-11-r133 | |
== < 2007 == | == < 2007 == | ||
Revision as of 17:03, 13 October 2010
Contents |
Currently Working on
Understanding E. Coli
Interests
Currently a graduate student at Boston College in Computational Biology. Still interested in a lot of the stuff below, but some focuses in Biology:
- genomics & next gen sequencing for variation discovery. - budding interest in regulatory genomics. - Read/Write biology.
Publications
COMIT: identification of noncoding motifs under selection in coding sequences
Coding nucleotide sequences contain myriad functions independent of their encoded protein sequences. We present the COMIT algorithm to detect functional noncoding motifs in coding regions using sequence conservation, explicitly separating nucleotide from amino acid effects. COMIT concurs with diverse experimental datasets, including splicing enhancers, silencers, replication motifs, and microRNA targets, and predicts many novel functional motifs. Intriguingly, COMIT scores are well-correlated to scores uncalibrated for amino acids, suggesting that nucleotide motifs often override peptide-level constraints.
Deniz Kural, Yang Ding, Jiantao Wu, Alicia M Korpi and Jeffrey H Chuang
http://genomebiology.com/2009/10/11/R133 (open access)
Genome Biology 2009, 10:R133,
doi:10.1186/gb-2009-10-11-r133
< 2007
About
I am a senior at Harvard College, concentrating in mathematics. I am interested in databases, and things like creative commons, open access, open source and so on. I am interested in the intersections of mathematics with biology, and to see if we can make more precise statements beyond "We have observed that protein X was expressed at higher levels". I am also interested in things like Web 2.0, the semantic wiki, machine-readability, data visualization and such as well.
Useful Thing
How to install the latest Biopython on Ubuntu This is probably terribly outdated.
Assignments (2007 Harvard Biophysics 101)
Follow the links to the corresponding assignment
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